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Laszlo G. Meszaros Dept. Animal Physiology Univ. of Kaposvar , Hungary Argina Nutraceuticals

Cardiovascular Disease [70-80%] atherosclerosis [the disease of the arteries] endothelial dysfunction. Nutraceutical therapy. Laszlo G. Meszaros Dept. Animal Physiology Univ. of Kaposvar , Hungary Argina Nutraceuticals Hungary.

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Laszlo G. Meszaros Dept. Animal Physiology Univ. of Kaposvar , Hungary Argina Nutraceuticals

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  1. Cardiovascular Disease [70-80%]atherosclerosis [the disease of the arteries] endothelial dysfunction Nutraceutical therapy Laszlo G. Meszaros Dept. Animal Physiology Univ. of Kaposvar, Hungary ArginaNutraceuticals Hungary

  2. “You’re as old as your arteries…” 1. AS is responsible for more death than any other disease. 2. Notonly deadly infarct and stroke, but overall well-being. 3. 6 out of 10 deadliest risk factors directly relate to AS. 4. No. 1 “risk factor” of AS is diet and life-style. 5. AS is a degenerative disease.

  3. AS is a degenerative disease Degenerative diseases: AS, Most types of cancer, Metabolic disease, Type-2 diabetes, Alzheimer’s, (Osteo)arthritis, … Tomiyama H et al.: Hypertens. Res. 2004, 27:465) Error accumulation & Epigenetical changes are likely caused by diet and life style

  4. Who’s who? Grandpa and grandson somewhere in Africa. Can you guess?

  5. It’s easy, when you look at their faces… Santos PC et al.: Ethnicity and arterial stiffness in Brazil, Am. J. Hypertens, 2011, 24:278)

  6. So, there is hope… (age vs. disease) Error accumulation & Epigenetical changes are MORE THAN LIKELY caused by diet and life style

  7. Why diet? Why physical inactivity? Physical inactivity Activity: beneficial effect on arterial stiffness Inactivity → obesity: dyslipidemia, metabolic syndrome, abdominal (visceral) fat as a dysfunctional “immune organ” that produces inflammatory cytokines Diet (in “developed” countries): Junk food (in every sense), Additives B-type malnutrition Waist circumference correlates stronger with CVD and MD than BMI.

  8. % of RDA – USDA, 2004 Vitamin: A E C B1 B2 B4 B6 Intake: 45 32 63 68 69 76 46 Only 15% of the population in the US consumes the recommended amounts of fruits and vegetables daily. More than 70% is vitamin D deficient. More than 90% is vitamin K2 deficient. Ames’s “Triage” theory Comments: RDA values are most likely underestimated… (vitamin D) “Extra” vitamins: omega 3, flavonoids, other phytonutrients… B-Type Malnutrition

  9. B-Type Malnutrition

  10. Reminder…

  11. Problems at the beginning… (chance to treat the initial cause?) • I/1 eNOS decreases with age • I/2 NO reacts with free radicals: • NO + O2- = ONOO- • I/3 ADMA that competes with L-arg • (Arginine-paradox) • II LDL-ch is VERY sensitive to oxidation • by free radicals • So, one thing is for sure: we need • efficient antioxidants. • And what else?

  12. Chance to treat the cause? An example: resveratrol Just look for the white arrows…

  13. How about arterial function? (reviewing the literature) 9 papers on FMD improvements by resveratrol (1921 papers all together on resveratrol benefits) 1 paper suggesting Q10 supplementation to decrease Aix 11 papers to show that grape polyphenols (antho- and procyanidines) improve FMD 3 papers on vitamin K2 decreasing vascular calcification 3 papers on plasma vitamin D decreasing arterial stiffness 21 papers to show that vitamin D improves other circulation parameters (coronary flow, for instance)

  14. Our results… 2 x 1 daily placebo or 150 mg grape seed procyanidines + 60 mg Aroniamelanocarpaanthocyanidines; test at the beginning and after 3 months PWV (m/s) Treated group (n=11) 0 3 12.41±1.13 9.74±0.82* * significant at P < 0.05 • Also significant reduction in systolic BP • Some decrease in LDL-ch (n=7)

  15. Our results… Regimen 1: 2 x 1 daily 150 mg GSE pro- + 60 mg Amanthocyanidines+ 10 mg resveratrol + 50 mg Q10 (water soluble) Regimen 2: regimen 1 + (2x1) 50 µg vitamin K2 and 1000 IU of vitamin D3) • Also significant reduction in BP • Significant increase in HDL-ch (n=5) • Significant improvement in EF

  16. So, it seems that… We have two choices: Or take vitamins and dietary supplements Thanks for listening…

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