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CHAPTER 15

CHAPTER 15. THE LUNG. LUNG. NORMAL PATHOLOGY. Congenital Atalectasis Acute Injury Obstructive vs. Restrictive Obstructive Restrictive. Vascular Infections Transplant Tumors Pleura. PATHOLOGY. Congenital Anomalies. Atalectasis (Collapse). Acute Lung Injury.

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CHAPTER 15

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  1. CHAPTER 15 THE LUNG

  2. LUNG • NORMAL • PATHOLOGY

  3. Congenital Atalectasis Acute Injury Obstructive vs. Restrictive Obstructive Restrictive Vascular Infections Transplant Tumors Pleura PATHOLOGY

  4. Congenital Anomalies

  5. Atalectasis (Collapse)

  6. Acute Lung Injury • Pulmonary Edema (Acute) • Acute Respiratory Distress Syndrome (ARDS), aka, Diffuse Alveolar Damage (DAD) • Acute Interstitial Pneumonia

  7. Pulmonary Edema • Hemodynamic • Microvascular Injury

  8. ARDS • Pathogenesis • Morphology • Clinical Course

  9. Acute InterstitialPneumonia

  10. OBSTRUCTIVE RESTRICTIVE OBSTRUCTIVEvs. RESTRICTIVE

  11. OBSTRUCTIVE • EMPHYSEMA • CENTRI-acinar (Centrilobolar) • PAN-acinar (Panlobular) • DISTAL Acinar (Paraseptal) • “Bullous” • Interstitial • Irregular

  12. OBSTRUCTIVE • Emphysema • Compensatory Hyperinflation vs. Obstructive Overinflation • Incidence • Pathogenesis • Morphology • Clinical Course

  13. Chronic Bronchitis • Pathogenesis • Morphology • Clinical Features

  14. ASTHMA • “Atopic” • NON-Atopic • Drug Induced • Occupational

  15. ASTHMA • Pathogenesis • Morphology • Clinical Course

  16. BRONCHIECTASIS • Etiology • Pathogenesis • Morphology • Clinical Course

  17. INTERSTITIAL • Infiltrative • Restrictive • Pathogenesis

  18. INTERSTITIAL • FIBROSING • PNEUMOCONIOSES • SILICOSIS • ASBESTOSIS • DRUG INDUCED • RADIATION INDUCED • GRANULOMATOUS • PULMONARY EOSINOPHILIA • SMOKING RELATED INTERST. DISEASE • PULMONARY ALVEOLAR PROTEINOSIS

  19. INTERSTITIAL • Fibrosing Diseases • Idiopathic Pulmonary Fibrosis • NON-Specific Interstitial Pneumonia • Cryptogenic Organizing Pneumonia • “Collagen” Diseases

  20. INTERSTITIAL • Pneumoconioses • Coal Workers • Silicosis • Asbestosis

  21. INTERSTITIAL • Drug Induced

  22. INTERSTITIAL • Radiation Induced

  23. GRANULOMATOUS • SARCOIDOSIS • HYPERSENSITIVITY PNEUMONITIS

  24. SARCOIDOSIS • Etiology • Pathogenesis • Immunologic Factors • Environmental Factors • Morphology • Clinical Course

  25. HYPERSENSITIVITY PNEUMONIA

  26. PULMONARY EOSINOPHILIA

  27. SMOKING RELATEDINTERSTITIAL DISEASES • “DESQUAMATIVE” Interstitial Pneumonia (DIP) • Respiratory Bronchiolitis-Associated Interstitial Lung Disease

  28. Pulmonary Alveolar Proteinosis (PAP)

  29. VASCULAR Diseases • Pulmonary Embolism (PE) (Hemorrhage, Infarction) • Pulmonary Hypertension • Diffuse Pulmonary Hemorrhage Syndromes

  30. PE

  31. Pulmonary Hypertension

  32. Diffuse Pulmonary Hemorrhage Syndromes • Goodpasture Syndrome • Idiopathic Pulmonary Hemosiderosis • Wegener Granulomatosis

  33. INFECTIONSPneumonia/Pneumonitis • Community Acquired Pneumonia • Community Acquired (Atypical) Pneumonia • Nosocomial (Hospital Acquired) Pneumonia • Aspiration Pneumonia • Lung Abscesses • Chronic Pneumonia • Pneumonia (Immunocompromised Patients) • HIV Lung Diseases

  34. Community Acquired • Streptococcus Pneumoniae • Haemophilus Influenzae • Moraxella Catarrhalis • Staphlococcus Aureus • Klebsiella Pneumoniae • Pseudomonas Aeruginosa • Legionella

  35. Community Acquired(Atypical) • Viral (Influenzal) • Mycoplasmal • Severe Acute Respiratory Syndrome (SARS)

  36. NOSOCOMIAL Pneumonia

  37. ASPIRATION Pneumonia

  38. LUNGABSCESS • Etiology • Pathogenesis • Morphology • Clinical Course

  39. CHRONIC Pneumonia • HISTOPLASMOSIS • BLASTOMYCOSIS • COCCIDIOMYCOSIS

  40. PNEUMONIA in Immunocompromised Hosts

  41. HIVLung Diseases

  42. LUNG Transplantation

  43. TUMORS • Carcinomas • Neuroendocrine Tumors • Miscellaneous Tumors • Metastatic Tumors

  44. CARCINOMAS • Etiology • Pathogenesis • Tobacco Smoking • Industrial Hazards • Air Pollution • Genetics

  45. CARCINOMAS • Squamous Cell • Adenocarcinoma • Large Cell • Small Cell (“Oat” Cell) • Combined

  46. CARCINOMAS • Staging • Paraneoplastic Syndromes

  47. Neuroendocrine Tumors(Carcinoids) • Relationship to Small Cell • Morphology • Clinical Features

  48. Misc. Tumors

  49. METASTATIC Tumors

  50. PLEURA • Normal Development and Structure • Effusion • Pneumothorax • Tumors

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