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Bioinformatic Quest for the Holy Grail: UG gene

Bioinformatic Quest for the Holy Grail: UG gene. Su Dong Kim Biointelligence Lab. Interdisciplinary Program in Cognitive Science, Seoul National University 2003. 2. 19. Bioinformatic Quest for the Holy Grail: UG gene. Logical necessity of UG Evolution of UG

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Bioinformatic Quest for the Holy Grail: UG gene

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  1. Bioinformatic Questfor the Holy Grail: UG gene Su Dong Kim Biointelligence Lab. Interdisciplinary Program in Cognitive Science, Seoul National University 2003. 2. 19. (C) 2002, SNU Biointelligence Lab, http://bi.snu.ac.kr/

  2. Bioinformatic Questfor the Holy Grail: UG gene • Logical necessity of UG • Evolution of UG • Brain structure and Language Disorders • Language Disorders & UG • SLI & WS • FOXP2, language gene • Cognitive Genetics • Bioinformatic Quest

  3. Logical necessity of UG

  4. Evolution of UG

  5. Why Study Language Disorders? • To locate language in the brain • To reveal workings of the grammar

  6. Brain Structure and Aphasia

  7. Language Disorders & UG • Having language localized in a specific area of the brain predicts the following: – impaired linguistic ability with regular intelligence – impaired general intelligence with regular linguistic ability • Specific Language Impairment (SLI) • Williams’ Syndrome (WS)

  8. Specific Language Impairment • Has a specific genetic profile • Slow rate of speech • Stopped to correct themselves 5X more than normal • OK with saying if words are English or not: Problems with inflection (tense, number)

  9. Genetic Study Results of SLI

  10. Pedigree of the KE family

  11. PET & MRI Study of the KE family (A) Parasaggital section (PET) (B) Coronal section (PET) (C) Transverse section (MRI)

  12. Identification of FOXP2 gene

  13. Phylogenetic Map of FOXP2

  14. Williams’ Syndrome (WS) • Genetic hallmark; – deletion on chromosome band 7q11.23. • Physical characteristics: – elfin appearance – particular heart defects • Cognitive problems: – only rudimentary skills in reading, writing, math – problems with spatial understanding • Normal to superior linguistic abilities; – very expressive and fluent

  15. Brain Cytoarchitectonic in WS

  16. Neurophysiological Profile of WS

  17. Molecular Genetic Profile for WS

  18. Genetics and Cognitive Ability

  19. Bioinformatic Questfor the Holy Grail: UG gene

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