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Application of Conditioning to the Study of Drug Addiction. Conditioned Place Preference with drugs of abuse uses Pavlovian conditioning procedures CS * UCS R CS R e.g. Light Stimulus*Drug approach response
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Conditioned Place Preference with drugs of abuse uses Pavlovian conditioning procedures CS * UCS R CS R e.g. Light Stimulus*Drug approach response Light Stimulus approach response Self-Administration of drugs of abuse uses Instrumental conditioning procedures R SR e.g. Lever press response drug delivery
Conditioned Place Preference stay Drug-injected Not Drug-injected don’t stay Pre-conditioning Preference Tests Days 1 and 2 Conditioning Sessions Days 3-10 Post-conditioning Preference Tests Days 11 and 14
Some drugs that are self-administered by laboratory animals Stimulants Narcotics Anxiolytics Other Fentanyl Cocaine Phencyclidine (PCP) Chlordiazepoxide d-Amphetamine Heroin Diazepam Nicotine Methylphenidate Codeine Pentobarbital Ethanol Ketamine Methamphetamine Methadone D9 THC Morphine
Self-Administration Model of Relapse incorporates both Instrumental and Pavlovian Conditioning No Cocaine and No Cues Cocaine Cues Alone Cocaine + Cocaine Cues
Amygdalaactivated Amygdalanot lit up Front of Brain Back of Brain Nature Video Cocaine Video Childress et al 1999 Cocaine Cue-Induce Craving
Grant et al 1996 Cocaine Cue-Induce Craving
In the laboratory...... • Study the brain sites that mediate conditioned relapse-like behavior • Determine the molecules that give rise to conditioned relapse-like behavior • (e.g., genes; proteins) • Test medications that may reduce conditioned relapse-like behavior • Study the consequences of conditioned drug use • (e.g., neurocognitive; brain plasticity changes)