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Application of Conditioning to the Study of Drug Addiction

Application of Conditioning to the Study of Drug Addiction. Conditioned Place Preference with drugs of abuse uses Pavlovian conditioning procedures CS * UCS R CS R e.g. Light Stimulus*Drug approach response

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Application of Conditioning to the Study of Drug Addiction

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  1. Application of Conditioning to the Study of Drug Addiction

  2. Conditioned Place Preference with drugs of abuse uses Pavlovian conditioning procedures CS * UCS R CS R e.g. Light Stimulus*Drug approach response Light Stimulus approach response Self-Administration of drugs of abuse uses Instrumental conditioning procedures R SR e.g. Lever press response drug delivery

  3. Conditioned Place Preference stay Drug-injected Not Drug-injected don’t stay Pre-conditioning Preference Tests Days 1 and 2 Conditioning Sessions Days 3-10 Post-conditioning Preference Tests Days 11 and 14

  4. Intravenous Cocaine Self-Administration

  5. Some drugs that are self-administered by laboratory animals Stimulants Narcotics Anxiolytics Other Fentanyl Cocaine Phencyclidine (PCP) Chlordiazepoxide d-Amphetamine Heroin Diazepam Nicotine Methylphenidate Codeine Pentobarbital Ethanol Ketamine Methamphetamine Methadone D9 THC Morphine

  6. Self-Administration Model of Relapse incorporates both Instrumental and Pavlovian Conditioning No Cocaine and No Cues Cocaine Cues Alone Cocaine + Cocaine Cues

  7. Cue-Induced Relapse to Cocaine-Seeking Behavior

  8. Amygdalaactivated Amygdalanot lit up Front of Brain Back of Brain Nature Video Cocaine Video Childress et al 1999 Cocaine Cue-Induce Craving

  9. Grant et al 1996 Cocaine Cue-Induce Craving

  10. In the laboratory...... • Study the brain sites that mediate conditioned relapse-like behavior • Determine the molecules that give rise to conditioned relapse-like behavior • (e.g., genes; proteins) • Test medications that may reduce conditioned relapse-like behavior • Study the consequences of conditioned drug use • (e.g., neurocognitive; brain plasticity changes)

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