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Rescue for opioid abused patient. Northeastern University SungHyun Choi. naloxone. Opioid drug?. Opioid is a medication that can relieve pain. It inhibits signals that are projecting to brain region where controls emotion. Inhibiting signals can decrease painful stimulus.
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Rescue for opioid abused patient Northeastern University SungHyun Choi naloxone
Opioid drug? • Opioid is a medication that can relieve pain. • It inhibits signals that are projecting to brain region where controls emotion. • Inhibiting signals can decrease painful stimulus. • Examples of opioid drugs are following: • Hydrocodone • Oxycodone • Morphine • Codeine • Diphenoxylate
Naloxone? • Naloxone is a narcotic antagonist that does not have any characteristics of drugs such as morphine. • Awhite powder that is soluble in water, dilute acid, and strong alkali. • Naloxone is generally used to prevent respiratory depression that is caused by overdose of opioid. • Even though the mechanism of naloxone is not fully understood yet, it effectively shows its function by competing same receptor site of opioid in the brain. • if opioid is not in the body, naloxone shows no effect. • naloxone is not dependent both physically and psychologically. • It does not have tolerance. • Intravenously administrating is the most effective way for naloxone. Source: http://opiophilia.blogspot.com/2013/07/opioid-antagonists-naloxone-and.html
SIDE EFFECTS OF NALOXONE?? • If naloxone would be injected more than necessary amount, increased blood pressure and seizure might be caused. • There are also some side effects of naloxone: • chest pain, severe vomiting, seizure, irregular heart rate, and severe headache
Step 1: sternal rub IMPORTATNT! Source: http://www.bupa.co.uk/individuals/health-information/directory/e/emergency-life-support
Step 2: Rescue breathing • Secure an airway not being blocked and put your cheek near one’s nose or moth and check if you could feel breathing . • It is very important to do rescue breathing correctly! If oxygen would not be provided in brain, one can die in only a few minutes! • If one would not breath…. • Place one on their back • Tip one’s head back after putting your hand on one’s neck • Pinch their nose to be closed • Seal over their mouth with your mouth and give 2 breaths. • Watch if their chest is rising as you give a breath. Give 1 slow breath every 5 seconds
Step 3: Naloxone Source: http://opiophilia.blogspot.com/2013/07/opioid-antagonists-naloxone-and.html
Step 4: continue rescue breathing • Dosage of naloxone for adult is different from one of naloxone for children: • For an adult, naloxone should be administered 0.4-2mg initially and repeat it with increased amount by 0.1-0.2mg every 2 to 3 minutes as needed. • The effect would last for 30 to 60 minutes • The maximum cumulative dosage that can be administered for an adult is 10mg. • Naloxone should be administered 0.1mg/kg/dose for children and maximum dosage for children is 8mg.
BIBLIOGRAPHY • CUNY. Naloxone(narcan). Retrieved 10/17, 2013, from http://eilat.sci.brooklyn.cuny.edu/newnyc/DRUGS/Naloxone.htm • Harm redcuction. (2013). Understanding naloxone. Retrieved 10/17, 2013, from http://harmreduction.org/issues/overdose-prevention/overview/overdose-basics/understanding-naloxone/ • Hospira. (2013). Naloxone official FDA information, side effects and uses. [Naloxone Official FDA information, side effects and uses] , 1. • Morepheen. (2013, 07/20). Opioid antagonist:Naloxone and naltrexone. Message posted to http://opiophilia.blogspot.com/2013/07/opioid-antagonists-naloxone-and.html • Naloxone dosage. Retrieved 10/17, 2013, from http://www.drugs.com/dosage/naloxone.html • Natalie Heaton. (2013). Emergency life support and CPR. Retrieved 10/17, 2013, from http://www.bupa.co.uk/individuals/health-information/directory/e/emergency-life-support • Prescribe to Prevent. (2013). Prescribe naloxone now! Retrieved 10/17, 2013, from http://prescribetoprevent.org/prescribe-naloxone-now/ • stopoverdose.org. (2013). Naloxone pro brochure. Unpublished manuscript. • Wolters Kluwer Health. (2013). Naloxone. [Naloxone: Indications, Side effects, Warning-Drugs.com] Facts and Comparisons at Drugs.Com, , 1.