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Pulmonary Embolism Extraction Catheter Development

The project aims to create a catheter to efficiently remove pulmonary embolisms, reducing fatalities. Design parameters include safe vessel interaction and easy maneuverability. Future work involves collaboration with experts.

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Pulmonary Embolism Extraction Catheter Development

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  1. Pulmonary Embolism Extraction Catheter Development Trip Cothren Lauren Nichols Dustin Temple Advised by: Dr. Michael Barnett, VUMC Cardiology

  2. Problem • There are over 600,000 cases of pulmonary embolisms annually in the United States, which result in nearly 60,000 fatalities. • Blood thinning, thrombolytics are dangerous • Need a catheter that can quickly and effectively remove pulmonary embolisms

  3. Goals • The goal of this project is to design a catheter that can efficiently remove an embolism from the pulmonary artery. The main goals of the project are: • To research and evaluate current technology in pulmonary embolism extraction • To design a catheter that can successfully remove embolisms percutaneously and completely without damage to the patient • To produce a feasible prototype of our design

  4. Existing Work • Much catheter work done to remove embolisms in the brain • Cardiac catheters typically focus on placing stents in coronary arteries • Few existing PE extraction catheters

  5. AngioJet Example

  6. Trellis Device • A peripheral infusion system that disperses a clot-lysing drug at 500-3000 rpm’s. • Demonstration Video • Device Website

  7. Potential Problems • Hemolysis causes release of adenosine when cells lyse • Bradycardia or heart failure • Renal failure • Unpredictable thrombolytic tolerance • Mechanical damage to vessel wall

  8. Design Parameters • Approximately 2 m in length • Device approximately 12 mm in diameter • Agitation and extraction mechanism • Does not harm vessel walls • Does not impede blood flow • Easily maneuverable

  9. Function Parameters • Time frame of < 1 hr • Embolus located via x-ray angiography • Typically done by interventional radiology or cardiothoracic • Clot age affects composition • Downstream protection not as important • Do not want systemic thrombolytics

  10. Current Work • Decide local thrombolytic elution • Obtain catheter from VUMC to examine • Schedule a surgery observation • Research best modeling mechanism for demo and CAD model

  11. Future Work • Meet with Dr. Barnett and Dr. Bream to discuss feasibility of ideas • Contact Dr. Byrne in VUMC Cardiothoracic Surgery • Create CAD model • Assemble team of contacts in VUMC and BME department

  12. References • http://www.medgadget.com/archives/img/sidcath.jpg • http://www.socalcardiology.com/media/angiojet.jpg • http://www.lexmed.com/images/cathphoto2.jpg

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