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Individual CB6 F1 mice develop multiple morbidities

Individual CB6 F1 mice develop multiple morbidities. Histopathology at death from 52 animals, aged 24-32 months. Diseases in this pool of CB6 F1 mice. Mice with multiple morbidities. % of individuals. Number of lesions. Number of Diseases. J. Exp. Med 210:2223 (2013 ).

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Individual CB6 F1 mice develop multiple morbidities

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  1. Individual CB6 F1 mice develop multiple morbidities Histopathology at death from 52 animals, aged 24-32 months Diseases in this pool of CB6 F1 mice Mice with multiple morbidities % of individuals Number of lesions Number of Diseases

  2. J. Exp. Med 210:2223 (2013) Note: This paper is from intramural researchers at NIA and NCI

  3. Aged mice respond differently to interventions In ischemia / reperfusion, two different treatments (sevoflurane and a GSK3b agonist) work in young but not in old GSK3b agonist Y O Sevoflurane - + - + SB-216763 Infarct Size Li H et al. – ActaAnaesthesiolScand 57:1024 (2013) Zhu J et al. – Am J PhyssiolCircPhysiol 300:H922 (2011)

  4. Smith MA & French AM Psychopharmacology 162:255 (2002) Montalvo-Ortiz et al. PNeuropsychopharmacology 39: 1469 (2014)

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