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Josh Snyder, MGH (algorithms) Dennis Jen, MGH (algorithms) Alex Yarmarkovich, BWH

EPI to conventional T1 registration: Develop software tool which can improve upon accuracy and/or robustness of affine registration of an EPI image to a conventional T1 image. Plan/Expected Challenges/Publication. Team. 1. Comparison tool to evaluate output quality compared to affine tools.

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Josh Snyder, MGH (algorithms) Dennis Jen, MGH (algorithms) Alex Yarmarkovich, BWH

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  1. EPI to conventional T1 registration:Develop software tool which can improve upon accuracy and/or robustness of affine registration of an EPI image to a conventional T1 image. Plan/Expected Challenges/Publication Team 1. Comparison tool to evaluate output quality compared to affine tools. 2. Working BSpline implementation. 3. Tuned BSpline implementation compared to affine implementations (Slicer, FSL’s flirt). Josh Snyder, MGH (algorithms) Dennis Jen, MGH (algorithms) Alex Yarmarkovich, BWH Xiaodong Tao, GE (engineering) Luis Ibanez, Kitware (engineering) Andy Saykin, Dartmouth (clinical) Expected Date for Insight Journal Publication: (Add picture to illustrate accomplishment) Accomplished by end of Programming Week, 2006 Working tool. Apparent better match than affine. Still tuning.

  2. Team Plan/Expected Challenges Dave Tuch, MGH (algorithms) (contact) Josh Snyder, MGH (algorithms) Sandy Wells, BWH (algorithms consultant) Luis Ibanez, Kitware (software) Andy Saykin, Dartmouth (clinical) Software: Provide guidance on optimal use of ITK reg methods. Clinical: Validation of results. Accomplished by end of Programming Week, Boston 2005 Motivated fuller support for image orientation in Slicer and ITK Expanded understanding of metric and optimizer parameters Produced working rigid registration Identified possible approaches for non-rigid component EPI to MR Registration:Develop software tool which can perform robust non-rigid, intrasubject registration between an EPI image and a conventional structural image. Algorithms: • Write testing harness for validation of results. • Identify suitable registration method available in ITK and optimal parameters. • Refine as necessary

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