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Water Power Peer Review

Water Power Peer Review. Zheng Zhang, Ph.D. Semprus BioSciences 1 Kendall Square. Building 1400, Cambridge, MA 02139 617/577-7755 x213 j onathan.zhang@semprusbio.com September 22, 2011.

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Water Power Peer Review

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  1. Water Power Peer Review Zheng Zhang, Ph.D. Semprus BioSciences 1 Kendall Square. Building 1400, Cambridge, MA 02139 617/577-7755 x213 jonathan.zhang@semprusbio.com September 22, 2011 Environmentally Benign and Permanent Modifications to Prevent Biofouling on Marine and Hydrokinetic Devices

  2. Purpose, Objectives, & Integration Purpose: Develop environmentally benign and permanent modifications to prevent biofouling on marine and hydrokinetic (MHK) devices. Objectives: Offer improvements and enhancements to MHK systems in the following segments related to biofouling: • Energy efficiency • Reliability • Power quality • Environmental impact • Maintenance costs Integration: Expect to outperform currently used nontoxic underwater coatings in biofouling resistance and be ready for the next stage of development with demonstration in MHK systems.

  3. Technical Approach • Design and develop modification systems applicable for permanent anti‐fouling modifications. (Planned completion date: 9/30/2011) • Monomer and polymer synthesis • Modification formulation development • Curing/applying method development • Characterization and stability evaluation • Demonstrate a broad spectrum of anti‐biofouling performance, long‐term efficacy and biocompatibility. (Planned completion date: 12/31/2011) • Protein adsorption assay • Bacterial/biofilm assay • Barnacle assay • Biocompatibility evaluation • 60‐day field test

  4. Key Issues and Unique Approach Key Issues • Broad spectrum of anti-fouling efficacy • Mechanical properties, applicability, and compatibility to current underwater coatings • Long-term stability and anti-fouling performance • Translation to field efficacy Unique Approach • Molecular design of betaine-based monomers and polymers to resist bio-fouling. • Optimized formulations and applying conditions to achieve high anti-fouling efficacy with mechanical performance and stability • Modification and application adaptable to current underwater coating systems. • Demonstration of anti-fouling performance with model fouling organisms and a 60-day field test

  5. Plan, Schedule, & Budget Schedule: • Initiation date: January 1, 2011 • Planned completion date: December 31, 2011 • Milestones for FY10 and FY11: • Milestone 1: Design modification systems and synthesize polymers applicable for permanent anti‐fouling modifications. Planned completion date: September 30, 2011 • Milestone 2: Demonstrate a broad spectrum of anti‐biofouling performance, long‐term efficacy, and biocompatibility. Planned completion date: December 31, 2011 Budget:

  6. Protein and Bacteria Reduction Betaine-Modified Silicone (PDMS) Betaine-modified aluminium panels (4”X8”) for a 60-day field test Aging Test with Artificial Seawater (ASW) Settlement of Barnacle Cyprids

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