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From Buffy Coat Platelets to Single Donor Platelets – A Feasibility Study. Dr. Sybesma, Sanquin Bloodbank Southeast, ‘s-Hertogenbosch, Netherlands St. Petersburg - June 9 th - 2004. Improvement of transfusion safety by reduction of donor exposure.
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From Buffy Coat Platelets to Single Donor Platelets – A Feasibility Study Dr. Sybesma, Sanquin Bloodbank Southeast, ‘s-Hertogenbosch, Netherlands St. Petersburg - June 9th - 2004
Improvement of transfusion safety by reduction of donor exposure • Variant Creutzfeldt-Jakob disease (Houston et al. 2000) • Septic platelet transfusion reactions (Ness et al. 2001) • Residual risk of viral infection (Soldan et al. 2003, Jackson et al. 2003) • HLA - (Slichter 1998) and HPA - refractoriness • TRALI • Unknown agents
Technical: donors selection: precount > 250, 70 kg Trima Accel, 100 procedures procedure time 70’ QC, splitting > 500 Economical: 434 Euro*pooled and single donor Logistical: autosufficient 2500 PLT per year * nov 2002 Donors and methods
Form 289 procedures: Citrate reactions: Mild: 37, Moderate: 1, Severe: 0 Collaps: 0 Haematoma: 5 Hyperventilation: 0 Donor reactions
TRIMA: 6 procedures per day 50 weeks 190 donors 8 donations per year* 2600 SDP per year 18 % drop-out by out-dating * Lazarus et al. 2001 Logistical feasibility
Cost price for SDP are less than revenues High split rates are beneficial for economical feasibility Revenues for SDP are higher than for BCP Cost of SDP are higher than for BCP Distribution of secondary costs over different components influence the cost of BCP Economical feasibility
Conversion is feasible economically, technically and logistically. Adequate donor selection + high collection performence assure high split-rates in relatively short procedure time. further research is needed on: how to keep donormotivation at high level donor recruitment and donor selection possibilities to reduce drop-out by outdating Cost / Qualy’s for pooled and apheresis PLT should be analyzed Conclusions