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A Naturopathic Perspective

A Naturopathic Perspective. Prostate Cancer Prevention and Treatment. Susan Fisher M.Sc.(Pharmacology), N.D. A Message to my Audience:. I enjoyed our discussion Wed night and wanted you to know my website (mahayacambridge.com) will be updated by mid-November.

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A Naturopathic Perspective

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  1. A Naturopathic Perspective Prostate Cancer Prevention and Treatment Susan Fisher M.Sc.(Pharmacology), N.D.

  2. A Message to my Audience: • I enjoyed our discussion Wed night and wanted you to know my website (mahayacambridge.com) will be updated by mid-November. • Also – of the veggies we discussed, choose to eat more of broccoli and cauliflower (I will explain more next time…)

  3. In the next 45 minutes… • Even the playing field • Inspire Health (Vancouver) • Inflammation • Nutrients in a Tomato • Whole Foods • Some Tools in my Toolkit

  4. Naturopathic Medicine Naturopathic medicine is a distinct system of primary healthcare Addresses the root cause of illness or disease Promotes health and healing using natural therapies

  5. NDvs MD / GP – Academic Background

  6. NDvs MD/GP – Academic Background Before Entry toMedical School Bachelor of Science

  7. NDvs MD/GP – Academic Background Anatomy, Histology, PathologyPhysiology, Pharmacology, Radiology, Biochemistry, Clinical Nutrition, Differential DiagnosisClinical Diagnosis, Immunology,Embryology, Public Health Naturopathic andConventional Medicine Years 1-3 Before Entry toMed School Bachelor of Science

  8. NDvs MD/ GP – Academic Background Natural Therapies etc. Drugs / Surgery Naturopathic / Conventional Medicine Years 3-4: Clinic Intern Anatomy, Histology, PathologyPhysiology, Pharmacology, Radiology, Biochemistry, Clinical Nutrition, Differential DiagnosisClinical Diagnosis, Immunology,Embryology, Public Health Naturopathic andConventional Medicine Years 1-3 Before Entry toMed School Bachelor of Science

  9. Clinical Nutrition • Examining the relationship between diet and health • Developing individualized diets • Treatments may include nutritional supplements like vitamins, minerals, enzymes and other nutraceuticals

  10. Lifestyle Counseling • Helping patients to make informed choices to be healthy • Understanding the physical, emotional, nutritional and environmental factors affecting well-being

  11. Body Mind Spirit SPIRIT BODY BODY MIND SPIRIT MIND Root Cause of Disease

  12. Botanical Medicine • Understanding the healing value of plant substances • Utilizing the plant substances and the knowledge of healing from around the world

  13. Curcumin /Turmeric (Curcuma longa)

  14. Green Tea (Camellia sinensis)

  15. Asian Medicine • Balancing the flow of Chi (energy) through meridian pathways • Includes the use of acupuncture and Oriental herbs

  16. Homeopathic Medicine • Stimulating self-healing mechanisms through the use of natural substances • Based on the principle that “likes cures like”

  17. Reducing Cancer Risk and Optimizing Survival Dr. Hal Gunn, M.D. CEO InspireHealth

  18. Role of the Tumour Microenvironment • The pattern of gene expression of cells in the tumour stroma is highly correlated with prognosis. • More highly correlated than tumour grade, whether the patient was treated with chemotherapy, or whether the cancer had spread to the lymph nodes. • Finak, G et al. Nature Medicine 14 (5) May 2008 518-27 • In other words, the environment of our body and what our immune cells are doing is the most important factor in determining prognosis

  19. The Human Macrophage

  20. The Human Macrophage M1:FIGHTINGINVADERS

  21. The Human Macrophage M1:FIGHTINGINVADERS M2:TISSUE REPAIR

  22. The Human Macrophage Invader Attacking RoleAcute Inflammationeg. Cut yourself OR Tissue Repair RoleChronic Inflammationeg. Arthritis, High Cholesterol, Obesity, Heart Disease, Diabetes, Autoimmune

  23. Positive Association of M1 Macrophages and Survival Ma J et al, The M1 form of tumor-associated macrophages in NSCLC is positively associated with survival time. BMC Cancer 2010 (10) 112

  24. MACROPHAGES: TWO IMPORTANT ROLES M1 : Invader Attacking Role Tumor suppression and invader / cancer cell destruction M1 Cells Attacking Tumor Inhibit cancer growth (acute inflammation)

  25. M2 Macrophages Help the Cancer Tumour to Grow • M2: Tissue Repair /Growth • -Growth factor production • Angiogenesis • Suppress immune function • Coordinate tissue growth M2 Cells: Helping tumorto grow larger. Promote cancer growth (chronic inflammation)

  26. Prostate Cancer is an Inflammatory Condition! • Interleukin-6 (IL-6), tumour necrosis factor (TNF), vascular endothelial growth factor (VEGF), fibroblast growth factors (FGF) are among the inflammatory substances believed contributing to growth of cancer • These cytokines are all elevated in Prostate cancer. • Extent of inflammation is monitored by CRP (C-reactive Protein level) and PSA levels

  27. How to Reduce Inflammation • Healthy alkaline diet (7+fruits/ veggies, water, omega-3 fats; limit alcohol /caffeine/ red meat) • Regular exercise • Absence of chronic diseases • Healthy stress reduction • Self-awareness and healthy emotional well being

  28. Reversing Rising PSA in Early Prostate Cancer • Control group: average 6% rise PSA 1 year. • 6 of 46 men progressed to surgery/radiation. • Treatment group: average 4% decline PSA 1 year. • None of the men progressed to surgery/radiation. • Journal of urology, 2005, 174:1065-1070

  29. Vegetarian diet Exercise Meditation Reversing Rising PSA in Early Prostate Cancer • Control group: average 6% rise PSA 1 year. • 6 of 46 men progressed to surgery/radiation. • Treatment group: average 4% decline PSA 1 year. • None of the men progressed to surgery/radiation. HEALTHY LIFESTYLE CHANGES

  30. Reversing Rising PSA in Early Prostate Cancer • Control group: average 6% rise PSA 1 year. • 6 of 46 men progressed to surgery/radiation. • Treatment group: average 4% decline PSA 1 year. • None of the men progressed to surgery/radiation. • Growth of LNCaP prostate cancer cells inhibited 70% by treatment group serum vs. Only 9% by control group serum.

  31. Mol NutrFood Res.2009 Feb53(2): 227-39

  32. Phytochemical and Ethnobotanical Databases Nutrients in: A Tomato www.Ars-grin.gov\duke

  33. Phytonutrients in a Tomato (1) 1',2'-EPOXY-1',2'-DIHYDRO-BETA-EPSILON-PSEUDOCAROTENE Fruit DUKE1992A 1',2'-EPOXY-1',2'-DIHYDRO-BETA-PSI-CAROTENE Fruit DUKE1992A 1,2-EPOXY-1,2-DIHYDRO-PSI,PSI-CAROTENE Fruit DUKE1992A 1-BUTYL-2-THIAZOL Fruit DUKE1992A 1-O-FERULOYL-BETA-D-GLUCOSE Fruit DUKE1992A 1-O-P-COUMAROYL-BETA-D-GLUCOSE Fruit DUKE1992A 10,16-DIHYDROXY-DECANOIC-ACID Fruit DUKE1992A 10,16-DIHYDROXY-HEXADECANOIC-ACID Fruit DUKE1992A 16-HYDROXY-HEXADECANOIC-ACID Fruit DUKE1992A 2,7-DIMETHYL-OCT-4-ENEDIOIC-ACID Shoot 1.2 DUKE1992A 2,7-DIMETHYL-OCTA-2,4-DIENOIC-ACID Shoot 1.8 DUKE1992A 2-BUTANONE Fruit DUKE1992A 2-PENTANONE Fruit DUKE1992A 2-PROPANONE Fruit DUKE1992A 24-(R)-ETHYL-LOPHENOL Seed DUKE1992A 24-METHYL-31-NOR-LANOST-9(11)-EN-3-BETA-OL Seed DUKE1992A 24-METHYL-LOPHENOL Seed DUKE1992A 24-METHYLENE-CYCLOARTANAL Seed DUKE1992A 24-METHYLENE-CYCLOARTENAL Plant DUKE1992A

  34. Phytonutrients in a Tomato (2) • 3-BETA-HYDROXY-5-ALPHA-PREG-16-EN-20-ONE Shoot DUKE1992A • 3-O-FERULOYL-QUINIC-ACID Leaf DUKE1992A • 31-NOR-LANOST-8-EN-3-BETA-OL Seed DUKE1992A • 31-NOR-LANOST-8-EN-3-BETA-OL Seed DUKE1992A • 31-NOR-LANOST-9(11)-EN-3-BETA-OL Seed DUKE1992A • 31-NORCYCLOARTENAL Seed DUKE1992A • 4-ALPHA-24-DIMETHYL-CHOLESTA-7,24-DIEN-3-BETA-OL Seed DUKE1992A • 4-ALPHA-METHYL-24-ETHYL-CHOLESTA-7,24-DIEN-3-BETA-OL Seed DUKE1992A • 4-VINYL-GUAIACOL Leaf DUKE1992A • 4-VINYL-GUAIACOL Seed DUKE1992A • 5,6-EPOXY-5,6-DIHYDRO-PSEUDO-PSEUDOCAROTENE Fruit DUKE1992A • 5-HYDROXYTRYPTAMINE Fruit DUKE1992A

  35. Phytonutrients in a Tomato (3) • ABSCISIC-ACID-1',4'-TRANS-DIOL Fruit DUKE1992A • ABSCISIC-ACID-1',4'-TRANS-DIOL Leaf DUKE1992A • ABSCISIC-ACID-1'O-BETA-D-GLUCOPYRANOSIDE Stem DUKE1992A • ACETALDEHYDE Fruit DUKE1992A • 5ALPHA-FUROSTANE-3BETA,22,26TRIOL-3-O-BETA-D-GLUCOPYRANOSYL... Plant DUKE1992A • 9,10,16-TRIHYDROXYHEXADECANOIC-ACID Fruit DUKE1992A • 9,10,18-TRIHYDROXY-OCTADECANOIC-ACID Fruit DUKE1992A • ABSCISIC-ACID Leaf DUKE1992A ALUMINUM Fruit 0.3 1700 DUKE1992A ARABIC-ACID Fruit DUKE1992A ARGININE Fruit 1 3637 DUKE1992A ARSENIC Fruit 0.003 0.043 DUKE1992A ASCORBIC-ACID Fruit 50 2952 DUKE1992A

  36. Phytonutrients in a Tomato (4) ACETIC-ACID Fruit DUKE1992A ACETONE Fruit DUKE1992A ADENOSINE Flower DUKE1992A ALANINE Fruit 30 4132 DUKE1992A ALPHA-AMYRIN Fruit DUKE1992A ALPHA-CAPROLACTONE Fruit DUKE1992A ALPHA-IONENE Fruit DUKE1992A ALPHA-KETO-GLUTARIC-ACID Fruit DUKE1992A ALPHA-LINOLENIC-ACID Fruit 30 496 DUKE1992A ALPHA-NONALACTONE Fruit DUKE1992A ALPHA-OCTALACTONE Fruit DUKE1992A ALPHA-OXOGLUTARIC-ACID Fruit DUKE1992A ALPHA-PINENE Fruit DUKE1992A ALPHA-TOCOPHEROL Fruit 7 143 DUKE1992A

  37. Phytonutrients in a Tomato (5) ASH Fruit 5700 105461 DUKE1992A ASPARAGINE Fruit 300 DUKE1992A ASPARTIC-ACID Fruit 1230 20332 DUKE1992A AUROXANTHIN Fruit DUKE1992A BETA-ALANINE Fruit 6 DUKE1992A BETA-AMYRIN Fruit DUKE1992A BETA-CAROTENE Fruit 7 113 DUKE1992A BETA-D-GLUCOPYRANOSYL-PHASEIC-ACID Plant DUKE1992A BETA-IONENE Fruit DUKE1992A BETA-SITOSTEROL Fruit DUKE1992A BETAINE Root 23 DUKE1992A BETAINE Shoot 69 DUKE1992A BIOTIN Fruit DUKE1992A BORON Fruit 0 96 DUKE1992A BUTANOL-2-ON-3 Fruit DUKE1992A

  38. Phytonutrients in a Tomato (6) BUTANOLS Fruit DUKE1992A BUTYROLACTONE Fruit DUKE1992A CADMIUM Fruit 0.005 1.7 DUKE1992A CAFFEIC-ACID Fruit 6 DUKE1992A CAFFEIC-ACID-4-O-BETA-D-GLUCOSIDE Fruit DUKE1992A CALCIUM Fruit 60 2400 DUKE1992A CALCIUM Leaf 60800 DUKE1992A CAMPESTEROL Fruit DUKE1992A CAPRYLIC-ACID Fruit DUKE1992A CARBOHYDRATES Fruit 43400 717400 DUKE1992A CARBOXYLIC-ACID Leaf DUKE1992A CELLULASE Fruit DUKE1992A CELLULOSE Fruit DUKE1992A CERIUM Fruit 7 60 DUKE1992A CHLORINE Fruit 510 DUKE1992A CHLOROGENIC-ACID Fruit 18 DUKE1992A

  39. Phytonutrients in a Tomato (7) CHOLINE Root 36 DUKE1992A CHOLINE Shoot 48 DUKE1992A CHROMIUM Fruit 0 3 DUKE1992A CINNAMALDEHYDE Fruit DUKE1992A CIS-3-HEXENOL-1 Fruit 4 40 DUKE1992A CIS-5'-BETA-PSEUDOCAROTENE Fruit DUKE1992A CIS-5'-EPSILON-PSEUDOCAROTENE Fruit DUKE1992A CIS-5'-NEUROSPORENE Fruit DUKE1992A CIS-5,CIS-5'-LYCOPENE Fruit 1 20 DUKE1992A CIS-5-LYCOPENE Fruit 1 20 DUKE1992A CIS-HEXEN-3-AL Fruit DUKE1992A CITRAL Fruit DUKE1992A CITRIC-ACID Fruit DUKE1992A CITROSTADIENOL Seed DUKE1992A COBALT Fruit 0 1.4 DUKE1992A COPPER Fruit 0.4 100 DUKE1992A CUTIN Fruit DUKE1992A CYCLOARTANOL Seed DUKE1992A CYCLOARTENOL Seed DUKE1992A CYCLOEUCALENOL Seed DUKE1992A ZEATIN-RIBOSIDE Flower DUKE1992A ZEAXANTHIN Fruit DUKE1992A ZETA-CAROTENE Fruit DUKE1992A ZINC Fruit 1 120 DUKE1992A ZIRCONIUM Fruit 0 4 DUKE1992A

  40. Phytonutrients in a Tomato (8) CYCLOHEXANOL Fruit DUKE1992A CYSTINE Fruit 120 1984 DUKE1992A DAMASCENONE Fruit DUKE1992A DECADIEN-TRANS-2,TRANS-4-AL Fruit DUKE1992A DIACETYL Fruit DUKE1992A DIHYDROXYTARTARIC-ACID Fruit DUKE1992A DIHYDROZEATIN Flower DUKE1992A EPOXY-5,6-IONENE Fruit DUKE1992A EPOXY-LUTEIN Fruit DUKE1992A ETHANOL Fruit DUKE1992A ETHYL-PHENOL Fruit DUKE1992A ETHYLENE Fruit DUKE1992A EUGENOL Fruit DUKE1992A TRIGONELLINE Root 69 DUKE1992A TRIMETHYL-2,6,6-HYDROXY-2-CYCLOHEXANONE Fruit DUKE1992A TRYPTAMINE Fruit DUKE1992A TRYPTOPHAN Fruit 1 1157 DUKE1992A TYRAMINE Fruit DUKE1992A TYROSINE Fruit 38 2479 DUKE1992A UBIQUINONE-10 Tissue Culture 60 DUKE1992A VALINE Fruit 1 3801 DUKE1992A VANADIUM Fruit 0 6 DUKE1992A VANILLIN Plant DUKE1992A VIOLAXANTHIN Fruit DUKE1992A VIT-B-6 Fruit 0 9 DUKE1992A WATER Fruit 910000 982000 DUKE1992A XANTHOPHYLL Fruit DUKE1992A YTTRIUM Fruit 0 6 DUKE1992A ZEATIN Fruit DUKE1992A ZEATIN-GLUCOSIDE Flower DUKE1992A FALCARINDIOL Seed DUKE1992A FALCARINOL Seed DUKE1992A FARNESAL Fruit DUKE1992A FARNESYL-ACETONE Fruit DUKE1992A FAT Fruit 1330 47441 DUKE1992A FAT Seed 150000 250000 DUKE1992A FERULIC-ACID Fruit DUKE1992A

  41. Phytonutrients in a Tomato (9) FALCARINDIOL Seed DUKE1992A FALCARINOL Seed DUKE1992A FARNESAL Fruit DUKE1992A FARNESYL-ACETONE Fruit DUKE1992A FAT Fruit 1330 47441 DUKE1992A FAT Seed 150000 250000 DUKE1992A FERULIC-ACID Fruit DUKE1992A FERULIC-ACID-O-BETA-D-GLUCOSIDE Fruit DUKE1992A FIBER Fruit 4700 77691 DUKE1992A FLUORINE Fruit 0.02 1.7 DUKE1992A FOLACIN Fruit 0 2 DUKE1992A FORMIC-ACID Fruit DUKE1992A FRUCTOSE Fruit 11700 DUKE1992A TARTARIC-ACID Fruit DUKE1992A TETRA-DECA-CIS-6-ENE-1,3-DIYNE-5,8-DIOL Stem DUKE1992A THIAMIN Fruit 1 10 DUKE1992A THREONINE Fruit 65 3637 DUKE1992A TITANIUM Fruit 0 140 DUKE1992A FUMARIC-ACID Fruit DUKE1992A FURFURAL Fruit DUKE1992A GABA Fruit 220 480 DUKE1992A GAMMA-CAROTENE Fruit DUKE1992A GENTISIC-ACID Leaf DUKE1992A GERANYL-ACETONE Fruit DUKE1992A TOMATIDA-3,5-DIENE Shoot DUKE1992A TOMATIDINE Plant DUKE1992A TOMATINE Flower DUKE1992A TOMATINE Leaf 6 8 DUKE1992A TOMATOSIDE-A Seed DUKE1992A TRANS-ACONITIC-ACID Fruit DUKE1992A

  42. Phytonutrients in a Tomato (10) GIBBERELLINS Fruit DUKE1992A GLUCOSE Fruit 16300 DUKE1992A GLUTAMIC-ACID Fruit 90 54053 DUKE1992A GLYCERIC-ACID Fruit DUKE1992A GLYCINE Fruit 23 3637 DUKE1992A GLYCOLIC-ACID Fruit DUKE1992A GLYOXAL Fruit DUKE1992A GRAMISTEROL Seed DUKE1992A GUAIACOL Fruit DUKE1992A HEMICELLULOSE Fruit DUKE1992A HEPTADIEN-TRANS-2,CIS-4-AL Fruit DUKE1992A HEPTADIEN-TRANS-2,TRANS-4-AL Fruit DUKE1992A HEPTULOSE Fruit DUKE1992A HEXADIEN-TRANS-2-,TRANS-4-AL Fruit DUKE1992A SILICON Fruit DUKE1992A SILVER Fruit 0 1.4 DUKE1992A SODIUM Fruit 10 6600 DUKE1992A SOLADULCIDINE Shoot DUKE1992A SOLANINE Fruit DUKE1992A SQUALENE Fruit DUKE1992A STARCH Fruit 120 10000 DUKE1992A STEARIC-ACID Fruit 80 1322 DUKE1992A STIGMASTEROL Fruit DUKE1992A STRONTIUM Fruit 0 140 DUKE1992A SUCCINIC-ACID Fruit DUKE1992A SUCROSE Fruit DUKE1992A SUGARS Fruit 15000 45000 DUKE1992A SULFOQUINOVOSYL-DIACYL-GLYCEROL Leaf DUKE1992A SULFUR Fruit 107 2330 DUKE1992A SYRINGALDEHYDE Plant DUKE1992A HEXANOLS Fruit DUKE1992A HISTIDINE Fruit 30 2149 DUKE1992A HYDROCINNAMALDEHYDE Fruit DUKE1992A I-VALERALDEHYDE Fruit DUKE1992A I-VALERIC-ACID Fruit DUKE1992A INDOLE-3-ACETIC-ACID Root DUKE1992A

  43. Phytonutrients in a Tomato (11) IODINE Fruit DUKE1992A IRON Fruit 1 800 DUKE1992A ISOAMYLOL Fruit 7 40 DUKE1992A ISOLEUCINE Fruit 210 3471 DUKE1992A ISOPENTENYL-ADENINE Root DUKE1992A ISOPENTENYL-ADENOSINE Root DUKE1992A ISOVALERALDEHYDE Fruit 0.006 DUKE1992A JSGGALACTURONIC-ACID Fruit DUKE1992A KAEMPFEROL Seed DUKE1992A KETOHEPTOSE Fruit DUKE1992A LACTIC-ACID Fruit DUKE1992A LANOSTEROL Seed DUKE1992A LEAD Fruit 0.003 60 DUKE1992A LEUCINE Fruit 330 5455 DUKE1992A LEUCINES Fruit 1 90 DUKE1992A LEUCIONPINE Tissue Culture DUKE1992A LEUCIONPINE-LACTAM Tissue Culture DUKE1992A LINALOL Fruit DUKE1992A LINOLEIC-ACID Fruit 830 13720 DUKE1992A PROTOPECTIN Fruit 11700 24200 DUKE1992A PYRUVIC-ACID Fruit DUKE1992A QUERCETIN Fruit DUKE1992A QUERCETIN-3-O-RHAMNOSIDE Fruit DUKE1992A QUERCITRIN Fruit DUKE1992A RIBOFLAVIN Fruit 1 8 DUKE1992A RISHITIN Plant DUKE1992A RUBIDIUM Fruit 0.3 22 DUKE1992A RUTIN Fruit DUKE1992A RUTIN Leaf 24000 DUKE1992A RUTINOSIDE Fruit DUKE1992A S-METHYL-METHIONINE Fruit 16 35 DUKE1992A SALICYLALDEHYDE Fruit DUKE1992A SELENIUM Fruit 0.001 0.034 DUKE1992A SERINE Fruit 57 3967 DUKE1992A

  44. Phytonutrients in a Tomato (12) LINOLENIC-ACID Fruit DUKE1992A LITHIUM Fruit 0.28 0.68 DUKE1992A LOPHENOL Seed DUKE1992A LUPEOL Plant DUKE1992A LUTEIN Fruit DUKE1992A LUTEIN-5,6-EPOXIDE Fruit DUKE1992A LUTEIN-EPOXIDE Fruit DUKE1992A LYCOPENE Fruit 1 20 DUKE1992A LYCOPERSICONOL Root DUKE1992A LYCOPERSICONOLIDE Root 6.7 DUKE1992A LYCOPHYLL Fruit DUKE1992A LYCOXANTHIN Fruit DUKE1992A LYSINE Fruit 20 5455 DUKE1992A MAGNESIUM Fruit 70 6000 DUKE1992A MAGNESIUM Leaf 4300 DUKE1992A MALIC-ACID Fruit DUKE1992A MANGANESE Fruit 0.6 100 DUKE1992A MERCURY Fruit 0.001 0.002 DUKE1992A METHANOL Fruit DUKE1992A PHOSPHORUS Fruit 110 8400 DUKE1992A PHOSPHORUS Leaf 5500 DUKE1992A PHYLLOQUINONE Plant 0.06 JN128:785 PHYTOENE Fruit DUKE1992A PHYTOENE-1,2-OXIDE Fruit DUKE1992A PHYTOFLUENE Fruit DUKE1992A PHYTOSTEROLS Fruit 70 1157 DUKE1992A PIPECOLIC-ACID Fruit DUKE1992A POLYGALACTURONASE Fruit DUKE1992A POTASSIUM Fruit 780 58800 DUKE1992A POTASSIUM Leaf 47000 DUKE1992A PROLINE Fruit 170 2810 DUKE1992A PROLINE Root 541 DUKE1992A METHIONINE Fruit 16 1322 DUKE1992A

  45. Phytonutrients in a Tomato (13) LYCOPERSICONOL Root DUKE1992A LYCOPERSICONOLIDE Root 6.7 DUKE1992A LYCOPHYLL Fruit DUKE1992A LYCOXANTHIN Fruit DUKE1992A LYSINE Fruit 20 5455 DUKE1992A MAGNESIUM Fruit 70 6000 DUKE1992A MAGNESIUM Leaf 4300 DUKE1992A MALIC-ACID Fruit DUKE1992A MANGANESE Fruit 0.6 100 DUKE1992A MERCURY Fruit 0.001 0.002 DUKE1992A METHANOL Fruit DUKE1992A METHIONINE Fruit 16 1322 DUKE1992A METHYL-2-BUTYRIC-ACID Fruit DUKE1992A METHYL-6-HEPTEN-5-ON-2 Fruit DUKE1992A METHYL-GLYOXAL Fruit DUKE1992A METHYL-SALICYLATE Fruit DUKE1992A MEVALONIC-ACID Fruit 3 4 DUKE1992A MOLYBDENUM Fruit 0 6 DUKE1992A MYRISTIC-ACID Fruit DUKE1992A N(6)-ISOPENT-2-ENYL-ADENINE Flower DUKE1992A N-DOTRIACONTANE Fruit DUKE1992A N-HENTRIACONTANE Fruit DUKE1992A N-HEXANOL Fruit DUKE1992A NEO-BETA-CAROTENE-B Fruit DUKE1992A NEO-BETA-CAROTENE-U Fruit DUKE1992A NEO-CHLOROGENIC-ACID Leaf DUKE1992A NEODYMIUM Fruit 2 30 DUKE1992A NEOLYCOPENE-A Fruit DUKE1992A N-PENTANOL Fruit 7 40 DUKE1992A N-TETRATRIACONTANE Fruit DUKE1992A N-TRITRIACONTANE Fruit DUKE1992A NARCOTINE Fruit DUKE1992A NARINGENIN Fruit DUKE1992A

  46. Phytonutrients in a Tomato (14) NEOLYCOPENE-B Fruit DUKE1992A NEOTIGOGENIN Tissue Culture 300 1500 DUKE1992A NEOXANTHIN Fruit DUKE1992A NESTIGOGENIN Fruit DUKE1992A NEUROSPORINE Fruit DUKE1992A NIACIN Fruit 6 99 DUKE1992A NICKEL Fruit 0.01 5 DUKE1992A NICOTIANAMINE Leaf DUKE1992A NITROGEN Fruit 1300 23330 DUKE1992A NITROGEN Leaf 26000 DUKE1992A NONACOSANE Fruit DUKE1992A O-CRESOL Fruit DUKE1992A O-HYDROXY-ACETOPHENONE Fruit DUKE1992A OBTUSIFOLIOL Seed DUKE1992A OLEIC-ACID Fruit 310 5124 DUKE1992A OXALIC-ACID Fruit 36 263 DUKE1992A P-COUMARIC-ACID Fruit DUKE1992A P-COUMARIC-ACID-O-BETA-D-GLUCOSIDE Fruit DUKE1992A P-HYDROXYBENZALDEHYDE Plant DUKE1992A PALMITIC-ACID Fruit 210 3471 DUKE1992A PALMITOLEIC-ACID Fruit 10 165 DUKE1992A PANTOTHENIC-ACID Fruit 1 61 DUKE1992A PECTIN Fruit 100 31000 DUKE1992A PECTINESTERASE Fruit DUKE1992A PENTANOLS Fruit DUKE1992A PENTEN-1-OL-3 Fruit DUKE1992A PHENOL Fruit DUKE1992A PHENOLICS Fruit 27 570 DUKE1992A PHENYL-2-ETHANOL Fruit DUKE1992A PHENYL-ACETALDEHYDE Fruit DUKE1992A PHENYLACETONITRILE Fruit DUKE1992A PHENYLALANINE Fruit 72 3801 DUKE1992A PHOSPHATIDYL-GLYCEROL Leaf DUKE1992A

  47. Psychoneuroimmunologyand Cancer • Chronic stress promotes tumour growth and angiogenesis inanimal model of ovarian cancer. Nature Medicine 2006; 12: 939-45 SPIRIT BODY MIND

  48. Cortisol and your Immune System IncreasedCortisol –(Stress Hormone) Decreased BodyDefenses

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