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How do we study brain/behavior relationships?

How do we study brain/behavior relationships?. Populations: Animal Models: advantages: disadvantages:. Human Models. populations with injuries or disease normal populations. Humans. History: phrenology:. Non-invasive ways of viewing brain function. Assessment of Structure vs Function.

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How do we study brain/behavior relationships?

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  1. How do we study brain/behavior relationships? • Populations: • Animal Models: • advantages: disadvantages:

  2. Human Models • populations with injuries or disease • normal populations

  3. Humans • History: • phrenology:

  4. Non-invasive ways of viewing brain function • Assessment of Structure vs Function

  5. Structure • CT or Cat Scan

  6. CT Scan

  7. Structure • CT or Cat Scan • 3 D xrays

  8. Structure • CT or Cat Scan • MRI's

  9. magnetic resonance imaging

  10. CT MRI

  11. Ways to look at function • EEG - electroencephalogram

  12. Ways to look at function • EEG – electroencephalogram • ERPs – evoked related potentials

  13. Ways to look at function • PET scans • rCBF – regional cerebral blood flow • Premise – more blood flow means more (neuronal) activity

  14. Ways to look at function • PET scans • rCBF • 2DG – 2 deoxyglucose • Premise – need for more sugar – need for more energy – more (neuronal) activity

  15. Ways to look at function • PET scans • rCBG • 2DG

  16. Structure and Function • fMRIs

  17. More Invasive methodology • Histological analysis • Lesion studies • Rationale – if an area is damaged and behavior changes….. the neurons in that area play a role?

  18. Electrical stimulation • Rationale: if we stimulate an area and we produce or stop a particular behavior….the neurons in that region are important for that behavior

  19. Delgado’s classic experiment

  20. Electrical stimulation • Pharmacological manipulations • Use of drugs and various agents

  21. a lot more techniques are available • Microdialysis- looks at the amount of neurotransmitter released in a region of the brain….

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