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Valvular Hemodynamics. Morton J. Kern, MD Professor of Medicine Chief of Cardiology Associate Chief Cardiology University California Irvine Orange, California. Hemodynamic Problems for the Cath Lab. Valvular heart disease: Aortic stenosis/insufficiency Mitral stenosis/insufficiency
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Valvular Hemodynamics Morton J. Kern, MD Professor of Medicine Chief of Cardiology Associate Chief Cardiology University California Irvine Orange, California
Hemodynamic Problems for the Cath Lab • Valvular heart disease: • Aortic stenosis/insufficiency • Mitral stenosis/insufficiency • Intraventricular gradients • Pericardial effusion/tamponade • Constrictive/restrictive physiology • Coronary Hemodynamics • Intracardiac Shunts
Pa/Ao valves close Pa/Ao valves open Pa/Ao valves are closed systole Tri/MV valves open Tri/MV valves close Tri/MV valves open =Valve action
BAMC Case #3117: Patient: 61 yo male Dx: 3V CAD filter: 50 Hz/ sample 250 Hz Normal LV and Aortic Pressure Fluid-filled system micromanometer transducers Fluid filled, FA sheath Pre Contrast
Aortic Stenosis Congenital bicuspid aortic stenosis Normal aortic valve
Mechanism of AS: LV-Ao Gradient • Consequences of LV-Ao Gradient: • late peaking Systolic murmur • Single A2 • Slow pulse upstroke
Hemodynamics of AS Peak to peak pressure gradients differ between ECHO and CATH Peak instantaneous P-P LV Unshifted=larger Grad Fusmann and Feldman T, Cath and CV Int 53:553;2001
Retrograde hemodynamic Assessment of Prosthetic Valves with a Pressure Wire Parham and Kern, Cath and CV Int 53:553;2001
Low Gradient AS. EF 25%, no CAD. Valve replacement? P-P gradient 30mmHg CO = 3.2l/m Fick AVA = 0.7cm2
Dobutamine challenge for LG AS P-P = 50mmHg CO = 4.2l/m AVA = 0.6cm2 Base 10 Dob+Pace 80 20 Dob + Pace 95
What should you do with Symptomatic AS patient, low gradient, low flow? The Dobutamine Challenge AVA = 0.7cm2 AVA = 1.0cm2 Fixed area AVA = 1.5cm2 Grayburn, P. A. Circulation 2006;113:604-606
Hemodynamics of Aortic Insufficiency • Greatest Diastolic Gradient early • Volume filling LV is rapid • LVEDP will be high unless compensated
Normal LA and LV diastolic pressures LA-LV Diastolic Gradient
Hemodynamics for the Cath Lab Low Gradient AS Complications of AVP – AI AS vs. HOCM Mitral Regurgitation after MVP for MS Diastolic CHF – constrictive v Restrictive Tamponade IntracardiacShunts