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Integrative physiology. Hemodynamics. Volume balance. osmotic balance. Oxygen transport. Acid-Base homeostasis. Cardiac Output. Frank-Starling law. The heart is a pump driven by its inflow (or pressure on its input). End diastolic pressere. Basic properties of blood vessels.
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Integrativephysiology Hemodynamics Volume balance osmotic balance Oxygen transport Acid-Base homeostasis
Cardiac Output Frank-Starling law The heart is a pump driven by its inflow (or pressure on its input) End diastolic pressere
Inlet pressure Flow The heart is a pump driven by its inflow (or pressure on its input)
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) Capillary and arteriolar resistances
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure Capillary and arteriolar resistances volume
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 V0 compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input) pressure P Capillary and arteriolar resistances V volume V0 compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances C1 C2 V volume V0 compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances < C1 C2 dV2 dV1 dP V volume V0 dV1/dP<dV2/dP compliance C=dV/dP
Elastic arteries Inlet pressure Flow Elastic veins The heart is a pump driven by its inflow (or pressure on its input pressure P Capillary and arteriolar resistances < C1 C2 V volume V0 dV1/dP<dV2/dP compliance C=dV/dP
Guyton experiments http://patf-biokyb.lf1.cuni.cz/~tribula/cirkulaceen/
Flow Q Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
Flow Q=0 Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
Flow Q=0 Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
Flow Q=0 Elastic arteries Elastic veins Pa The heart is a pump driven by its inflow (or pressure on its input Pv Capillary and arteriolar resistances
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv = Pa= Pm Q Capillary and arteriolar resistances Pm Pm – „mean circulatory pressure“ Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Pv=0 Q Capillary and arteriolar resistances Pm Pv
Flow Q cannot rise Elastic arteries Elastic veins Pv< 0 Pa Elastic veins collapses Pv Pv<0 Q Capillary and arteriolar resistances Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Flow Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Pv=0 Q Capillary and arteriolar resistances Pm Pv
Flow Q cannot rise Elastic arteries Elastic veins Pa Elastic veins collapes Pv Pv<0 Q Capillary and arteriolar resistances Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Flow Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Q Capillary and arteriolar resistances Pm Pv
Flow Q Elastic arteries Elastic veins Pa Pv Pv=0 Q Capillary and arteriolar resistances Pm Pv
Flow Q cannot rise Elastic arteries Elastic veins Pa Elastic veins collapes Pv Pv<0 Q Capillary and arteriolar resistances Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Venotonus Pv Pv= Pm Q Capillary and arteriolar resistances Pm Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Venotonus Pv Pv= Pm Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
Flow Q=0 Elastic arteries Elastic veins Pa = Pm Venotonus Pv Pv= Pm Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
Flow Q Elastic arteries Elastic veins Pa Venotonus Pv Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv
Flow Q Flow Elastic arteries Elastic veins Pa Venotonus Pv Blood Volume Q Capillary and arteriolar resistances Pm Pm Pv