1 / 7

Wireless Neural Activity Monitoring Environment for Rodents 01/27/12

Progress Update: W-NAME-R. Wireless Neural Activity Monitoring Environment for Rodents 01/27/12. Chaitali Biswas http://icslwebs.ee.ucla.edu/dejan/researchwiki/index.php?title=Wireless_Neuronal_Activity_Monitoring_Environment_for_Rodents. UCLA. Outline: 01/27/2012.

deliz
Download Presentation

Wireless Neural Activity Monitoring Environment for Rodents 01/27/12

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Progress Update: W-NAME-R Wireless Neural Activity Monitoring Environment for Rodents01/27/12 Chaitali Biswas http://icslwebs.ee.ucla.edu/dejan/researchwiki/index.php?title=Wireless_Neuronal_Activity_Monitoring_Environment_for_Rodents UCLA

  2. Outline: 01/27/2012 • Background – Why monitor brain injured rats? • Invasively • Wirelessly • Research Questions • Neuroscience / Neurosurgery • Neuroenginnering • Design • Established / Adopted / Under Discussion / Forecasted • Roadmap • Experiments & Presentations • Feedback from DMGroup DMGroup Progress Report: Chaitali Biswas: Jan 27 2012

  3. Why monitor brain injured rats? • Injury Variables • Insult Mechanics • Acute Indications • Chronic Indications • Hypothesis – quantifiable depression of hippocampal q • Theta [4,12]Hz phase sets R/W access • Theta power spectrum varies across hippocampus • Hippocampus := encoding + retrieval of spatial memory • Observable behavioral tasks • Learning enhanced by EEE DMGroup Progress Report: Chaitali Biswas: Jan 27 2012

  4. Characterizing Hippocampal Theta Bland et al, J Neurophys. 2002 • Spectrum [4, 12] Hz, max @ 8 Hz • Amplitude [10,100] uV • Time-Series Analysis: ??? • Types: Attentional vs. Translational • Phase varies with • Immediately Previous Activity • Cross-talk • Injury effects • Depresses amplitude • Downshifts peak frequency MANY QUESTIONS REMAIN DMGroup Progress Report: Chaitali Biswas: Jan 27 2012

  5. NS Questions for W-NAME-R Which stereotaxic coordinates offer max(SNR) correlated with spatial navigation during a working memory task in the uninjured rat brain? Which is the minimal set of intra-hippocampal loci where theta dysfunction may be detected and reliably correlated back to abnormal working memory task performance due to injury? What are differences in theta functionality between injured and uninjured subjects during (a) memory tasks (NOR/MWM/RAM) (b) exploration of enriched environment (EEE)? Can theta dysfunction in injured subjects be used as quantitative predictor of malperformance in working memory tasks subsequent to EEE training? DMGroup Progress Report: Chaitali Biswas: Jan 27 2012

  6. NE Questions for W-NAME-R What is optimal type and design of electrode for chronic monitoring of hippocampal theta? How many channels can be supported for raw theta [4,12]Hz x IP3, [6,8]bit ADC on 5g battery? How long on 1 change battery? How to design enriched environment cage? Time? Cost? How many rodents can be supported off 1 basestation transceiver? How to set up camera system to co-register tracked behavior w/ theta? Which algorithms correlate injury theta to abnormal navigation? Design a QEEG algorithm: theta waves  expected quantifiable behavior metrics DMGroup Progress Report: Chaitali Biswas: Jan 27 2012

  7. Experiments & Presentations • Electrode Selection • Headstage Construction + WiFi Testing • Implantation Technique w/ Tethered Recording - sham • Headstage Installation - sham • Novel Object Recognition (NOR) Test – sham • Battery Life Test – sham • Headstage Retention by Animal – sham • Post-injury Implantation – TBI • Camera captured NOR behavior tracking – sham + TBI • Mapping theta to behavior – pattern detection • Presentation • ?: Neurotrauma: Abstract April 15 2012 • ?: Thesis Proposal: Fall 2012 DMGroup Progress Report: Chaitali Biswas: Jan 27 2012

More Related