Zeosen Natural Mineral Zeolite Clinoptilolite Animal Food Supplement Presentation

1. Livestock Supplement made from 100% Natural Minerals www.zeosen.com | hello@zeosen.com 1

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3. The Global Challenge • Achieve sustainable & natural farming, producing more yield, bigger and more nutritious better-tasting crops! Farm • Regenerative farming practice promoting the use of natural minerals in order to be less reliant on chemical fertilizers, chemical pesticides and eliminate the use of GMO’s. • Address landfill stress via waste food dehydration by turning food waste into soil additives, compost, chicken or fish feeds depending on input; therefore addressing the climate issue by reducing greenhouse gas emissions. Soil • Support local and indigenous group on sustainability through global partnership via the educational platform. Therefore creating jobs which eradicate hunger and poverty within a social enterprise project that is led by caring individual or group regardless of gender, status, stability, race, religion, and belief. Fork Our strategy is simple and our goals are clear. Together, we can make a difference! The UN SDG Goals we support 3

4. Our Mission We will use our knowledge and technology to inspire, create and implement solutions that will respond to food and health challenges of modern society Our Vision With technology and products, we will help to manufacture affordable food, supplements and medicine while creating comfortable environments for everyone on the planet Our Commitment We are building relationships with our customers that will make a difference in all our lives. Success and satisfaction of our product users is the very engine that will drive us forward PROTECT SAVE VALUE 4

5. Declining soil fertility - reducing sustainable development of agriculture Major Problem The latest report on The State of Food Security and Nutrition in the World complements the usual assessment of food security and nutrition with projections of what the world may look like in 2030 if trends of the last decade continue. Projections show that the world is not on track to achieve Zero Hunger by 2030 and, despite some progress, most indicators are also not on track to meet global nutrition targets. The food security and nutritional status of the most vulnerable population groups are likely to deteriorate further due to the health and socio-economic impacts of the COVID-19 pandemic. Climate change threatens our ability to ensure global food security, eradicate poverty and achieve sustainable development. Greenhouse gas (GHG) emissions from human activity and livestock are a significant driver of climate change, trapping heat in the earth's atmosphere and triggering global warming. Climate change has both direct and indirect effects on agricultural productivity including changing rainfall patterns, drought, flooding and the geographical redistribution of pests and diseases. The vast amounts of CO₂ absorbed by the oceans cause acidification, influencing the health of our oceans and those whose livelihoods and nutrition depend on them. Source: SOFI 2020: The State of Food Security and Nutrition in the World, FAO, IFAD, UNICEF, WFP and WHO. FAO website accessed 30/10/2020 http://www.fao.org/publications/sofi/en/ ; http://www.fao.org/climate-change/en/ • Reduc'on of Soil and leaf nitrogen- fixing bacteria • Overuse of chemical fer'lizers • Overuse of chemical pes'cides • Soil compac'on (human-caused) Major Causes 5

6. Why ZEOSEN Detoxifying Agent and Immune Booster Cracking the Livestock Performance Code • facilitates a slower passage of food through the digestive tract = a longe time for the resorption of nutrients • ZEOSEN is not subject to metabolism (it does not degrade; instead, it acts as a carrier of nutrients) What is ZEOSEN • adding clinoptilolite in colostrum reduces the incidence of diarrhoea syndrome in newborn calves (Zarcula et al., 2010; Sadeghi and Shawrang, 2008) • CaAl2Si7O18 • Other cations: Na+, K+, Mg2+ • increases mean blood serum leg concentration in newborn calves (Gvozdic et al., 2010) and increases values of apparent efficacy of absorption (Gvozdic et al., 2007) • Applicable for animal and human use • Ion-exchangers; adsorbents; animal feed additives, antacids, drugs (Enterex), anti-caking agents - EC12991, No. 2200/2001; October 17, 2001 • supplementation of clinoptilolite has no adverse effect on serum concentrations of fat-soluble vitamins (vit. A - retinol, vit. E - tokoferol) (Katsuolos et al., 2005) Micronization effects The technology behind ZEOSEN • Reduced particle size: 200 nm – 10 μm and increased specific surface • Finely micronized zeolite mineral with enhanced biological activity • Increased mesoporosity: a portion of total mesoporous surface within BET total surface exceeds 50% • Made with patented micronization technology 20 years in the making and constant improvements • Due to mentioned characteristics, a reactive portion of particle surface is increased, thus stronger interaction with biological tissues: • Environmentally friendly technology enabling improvement of various mineral substances • Suitable for fertilizers and mineral feed additive production 6

7. Immune modulation and Improved nutrient digestibility Toxin removal Zeosen interacts in galt which induces: Zeosen efficiently adsorbs and immobilizes: • Increased macrophage and DC response • Mycotoxins (ochratoxin and aflatoxin B1) • Nitrosamines • Dioxines • Heavy metals (Pb, Hg, Cd, As) and ammonia • Bacterial toxins and viruses • CD4 CD8 proliferation • Improvement of gut cellular barrier • J Cancer Res Clin Oncol. 2002 Jan;128(1):37-44. Epub 2001 Nov 10. Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. Pavelic K, Katic M, Sverko V, Marotti T, Bosnjak B, Balog T, Stojkovic R, Radacic M, Colic M, Poljak-Blazi M. Rudjer Boskovic Institute, Division of Molecular Medicine, Bijenicka 54, HR-10000 Zagreb, Croatia. • Adv Ther. 2004 Mar-Apr;21(2):135-47. Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system. Ivkovic S, Deutsch U, Silberbach A, Walraph E, Mannel M.Megamin GmbH, Berlin, Germany • Colloids Surf B Biointerfaces. 2005 Nov 25;46(1):20-5. Epub 2005 Sep 28. Adsorption of mycotoxins by organozeolites. Daković A, Tomasević-Canović M, Dondur V, Rottinghaus GE, Medaković V, Zarić S. Institute for Technology of Nuclear and Other Mineral Raw Materials, P.O. Box 390, 11000 Belgrade, Serbia and Montenegro. • Chemosphere 58 (2005) 109–114 Adsorption of nitrosamines in acidic solution by zeolites Chun Fang Zhou, Jian Hua Zhu Department of Chemistry, Nanjing University, Nanjing 210093, China • Journal of Colloid and Interface Science 280 (2004) 309–314. The removal of heavy metal cations by natural zeolites E. Erdem a, N. Karapinar b, R. Donat a,a Department of Chemistry, Faculty of Science and Arts, Pamukkale University, 20017 Denizli, Turkey-Department of Chemistry Engineering, Faculty of Engineering, Pamukkale University, 20017 Denizli, Turkey • Colloids Surf B Biointerfaces. 2008 Jun 15;64(1):88-97. Epub 2008 Jan 25. Selective adsorption of bacterial cells onto zeolites. Kubota M, Nakabayashi T, Matsumoto Y, Shiomi T, Yamada Y, Ino K, Yamanokuchi H, Matsui M, Tsunoda T, Mizukami F, Sakaguchi K.Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan. • Science Direct: Microporous Materials: 1387/1811 . Antiviral properties of clinoptilolite, Grce, Pavelic, Ruder Bosković Institute, Division of Molecular Medicine, Zagreb, Croatia 7

8. Silicon supplementation Zeosen is a highly effective source of bioavailable silicon (H4SiO4), therefore promoting: • Collagen and elastin synthesis • Faster bone growth and mineralization • Improved tendon strength (reduction of injury) • Faster growth and thicker and lustre hair (coat, fur) • J Cell Biochem. 1995 May;58(1):39-46. Zeolite A inhibits osteoclast-mediated bone resorption in vitro. Schütze N, Oursler MJ, Nolan J, Riggs BL, Spelsberg TC. Department of Biochemistry, Mayo Clinic, Rochester, Minnesota 55905, USA. • Autocrine signals promote osteoblast survival in culture A Tumber, M C Meikle and P A Hill Bone Biology Unit, Department of Orthodontics and Paediatric Dentistry, Guy’s, King’s and St Thomas’ Hospital’s Medical and Dental Schools, Guy’s Hospital, St Thomas’ Street, London SE1 9RT, UK • Adv Drug Deliv Rev. 2005 May 25;57(7):959-71. Epub 2005 Apr 15. Mechanism of osteoclast mediated bone resorption--rationale for the design of new therapeutics. Väänänen K. Department of Anatomy, Institute of Biomedicine, University of Turku, FI-20700 Turku, Finland. • Nutr Metab (Lond). 2013 Jan 8;10(1):2. doi: 10.1186/1743-7075-10-2. Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy. Jurkić LM1, Cepanec I, Pavelić SK, Pavelić K. Antioxidant effect Zeosen interacts in galt which induces: • SOD, Catalase and peroxidase enzymes are stimulated by MZ therefore reducing oxidation, peroxidation and lipid peroxidation • Micronized Zeolite adsorbs hydroxyl radical, molecule which wreaks havoc in body • Anticancer Res. 2003 Mar-Apr;23(2B):1589-95. Anticancer and antioxidative effects of micronized zeolite clinoptilolite. Zarkovic N, Zarkovic K, Kralj M, Borovic S, Sabolovic S, Blazi MP, Cipak A, Pavelic K.Ruder Boskovic Institute, Division of Molecular Medicine, Bijenicka 54, HR-10000 Zagreb, Croatia. • FREE RADICAL BIOLOGY AND MEDICINE 33-09/2002: The effect of MZM on TAS of Healthy individuals and patients with malignant diseases. Ivkovic S, Zabcic D. Megamin International • Biochem Biophys Res Commun. 2011 Jul 8;410(3):478-83. Epub 2011 Jun 7. Zeolites are effective ROS-scavengers in vitro. Pellegrino P, Mallet B, Delliaux S, Jammes Y, Guieu R, Schäf O. Laboratoire de Biochimie, Hôpital Timone, 27 Bd Jean Moulin, F-13385 Marseille Cedex 05, France. • Life Sci. 2013 May 20;92(17-19):903-10. Epub 2013 Apr 3. Dietary zeolite supplementation reduces oxidative damage and plaque generation in the brain of an Alzheimer's disease mouse model. Montinaro M1, Uberti D, Maccarinelli G, Bonini SA, Ferrari-Toninelli G, Memo M. 8

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10. ZEOSEN Mechanism of action • Due to small size, Zeosen interacts via intestinal epithelial cells (villi) and probiotic bacteria, thus modulating the immune system, enzymes and performing detoxification APPLICATION effects for use as small ruminants feed Benefits: • inclusion of clinoptilolite in diet has increment on intake and digestability of nutrients (Ruiz-Barrera et al 2006) • increases weight gain and daily live weight gain in sheep infested with nematodes (Deligiannis et al., 2005) • clinoptilolite in compound feed significantly reduces the faecal egg counts (FEC) in excrements (Deligiannis et al., 2005) • reduces oocyst Eimeria spp. output in supplemented ewes and reduces oocyst output of this parasite in lambs born from supplemented ewes (Alcala-Canto et al., 2011) • addition of clinoptilolite to starter diet of newborn lamb reduces incidence and severity of diarrhoea., although its effect on haematology and performance was negligible (Norouzian et al. 2010) • is effective in preventing toxic effects of zearalenone (Stojcic et al., 2004) Dosage: • 1% by weight of the feed composition Benefits of ZEOSEN on Animals High quality meat increase (up to 30%) due to: • Improved feed efficiency ratio • Better water consumption, • Enhanced nutrient utilization;  • Improved manure and litter condition, reduced ammonia • Prevention of aflatoxicosis;  • Prevention of respiratory diseases, Bacterial toxins and parasites • Improve the taste of meat;  • Increased immune system (fewer antibiotics use) 10

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12. Supplementary feed made of pure Zeolite Clinoptilolite Mineral ZEOSEN is effective in: • Positive modulation of the immune system • Supplementation of the essential minerals calcium, magnesium, and silicon (Si); subsequently providing positive outcome on animal bones, tendons and teeth, healthier and lustre hair • Elimination of harmful toxins (such as aflatoxins) and heavy metals from the animal gastrointestinal tract, which originates from food and water • Promoting digestibility, resulting in better utilization of nutrients, particularly proteins; Stimulation of production of host enzymatic antioxidants (SOD, GPx). For A Higher Nutrient Utilisation ZEOSEN Natural Zeolite (Clinoptilolite) Is an Active Dietary Fibre. It is known from the microbiological technology that the microbes surviving in the matrixes usually live longer and are more active than microbes fleeting in the solution. This is also valid for the microflora of the stomach. Natural Zeolite (Clinoptilolite) has a huge surface of 360 sq.m per gram. In opposite to the common carriers of crude fibres, the mineral ballast material Natural Zeolite (Clinoptilolite) has decisive advantages. It is rather broken down by the animal organism nor by the surviving microbes in the stomach-intestine tract. While the organic carriers of crude fibres mostly contain 10 – 30 % ballast materials, Natural Zeolite (Clinoptilolite) can be applied to almost 100 % as an effective ballast material; it relatively doesn't require but little place being anyhow short in modern recipes and rations. The Zeosen (Zeolite Clinoptilolite) Feed additive for Organ Discharge and Better Stable Climate Especially in the high-end breeding is the production of ammonia in the digestive tract a big problem. The solution to this problem is Natural Zeolite (Clinoptilolite). The high clinoptilolite content of over 80%, binds the toxic ammonia. The liver is discharged in the detoxification process. Detoxifying Agent and Immune Booster Cracking the Livestock Performance Code 12

13. The science you can trust to We are making sure to have #1 quality supported by research and development partners around the world. Our collaboration, association and partners: Acib (Austria), Institute Rudjer Boskovic (Croatia), Eurofins (Germany), GreenPharma (France), Schrodinger LLC (USA), Biafin (Germany), EkoBiogen (Germany), Biosens (UK) We constantly push the science limits in our efforts to reach the determined goals. Equipped with experience, hard work and collaboration with reputable institutions in the field, we are taking a step further each day. Achieving Excellence We apply exceptional practices in managing and achieving results. Our greatest value belongs to continuous technological advancement which allows us to satisfy the most demanding needs in a business niche Followed by repeated production improvements, technological modifications and product efficacy studies, we achieved compelling results in the area not only of agricultural but for medical and food market segment. Compliance Our company ensures the highest quality of production, fast distribution of products. This includes control of manufacturing processes as a systematic preventive approach to food safety from biological, chemical and physical hazards. 13

14. Sustainable, Natural and Organic Detoxifying Agent and Immune Booster Cracking the Livestock Performance Code www.zeosen.com email us at - hello@zeosen.com Farm Together, we can make a difference! Soil Fork ZED 14

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