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Regulation by the Heme Cofactor in Proteins

Regulation by the Heme Cofactor in Proteins. Robert W. Clark Visiting Assistant Professor Chemistry clarkr@hope.edu. B.S., Central Michigan University, 1999 M.S., University of Wisconsin-Madison, 2001 Ph.D., University of Wisconsin-Madison, 2005. Heme-specific inhibition

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Regulation by the Heme Cofactor in Proteins

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  1. Regulation by the Heme Cofactor in Proteins Robert W. Clark Visiting Assistant Professor Chemistry clarkr@hope.edu B.S., Central Michigan University, 1999 M.S., University of Wisconsin-Madison, 2001 Ph.D., University of Wisconsin-Madison, 2005 Heme-specific inhibition in a Ca2+-regulated K+ channel? Clark Research Group Spring 2006 Areas of expertise:Bioinorganic Chemistry, Mechanistic Studies of Heme Proteins, Spectroscopic Studies of Metalloporphyrins • Roles of Heme in Proteins • O2 storage & transport • electron transfer • catalysis • regulation of protein function Representative publications: Clark, R.W., Lanz, N. D., Lee, A. J., Kerby, R. L., Roberts, G. P., and Burstyn, J. N. (2006)Unexpected NO-Dependent DNA Binding by the CooA Homolog from Carboxydothermus hydrogenoformans, Proc. Natl. Acad. Sci. USA 103, 891-896. Clark, R. W., Youn, H., Lee, A. J., Roberts, G. P., and Burstyn, J. N.DNA Binding by an Imidazole-Sensing CooA Variant is Dependent on the Heme Redox State. (manuscript in preparation) Pinkert, J. P., Clark, R. W. and Burstyn, J. N. Modeling Proline Ligation in the Heme-Dependent CO Sensor, CooA, Using Small Molecule Analogs (manuscript submitted to J. Biol. Inorg. Chem.) Clark, R. W., Youn, H., Parks, R. B., Cherney, M. M., Roberts, G. P., and Burstyn, J. N. (2004) Investigation of the Role of the N-Terminal Proline, the Distal Heme Ligand in the CO Sensor CooA, Biochemistry 43, 14149-14160. Transcriptional regulation by the CO sensor from R. rubrum

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