Poster Draft from Bioengineering’s Capstone Design Course

1. Poster Draft from Bioengineering’s Capstone Design Course

3. Add Dept. of BIOE and contact info Cut

4. TEAM LA ER NanoStitch A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar Good decision to use bold to call attention to description of your design, but this large block of text doesn’t provide an easy entry point into the poster. Reorganize and edit! Introduction Nanostitch Technical Specifications Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques,Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin. Laser Mounting Bracket Temperature Sensor Motor Safe and Effective Solution Device Concept Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device Results coming Insert graph of tensile strength of Nanostitch vs. Suture Results coming Proximity Sensor • Size of Wound: 2-5cm • Maximum Safety • Highly Consistent • Highly Repeatable Dampened Arm Safety Concerns Addressed User Interface Conclusions Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure Patient Safety • Temperature monitoring prevents damage to skin • Modulated laser intensity to prevent burns • Reduced manipulation of wound  Less opportunity for infection • Motorized angle adjustment allows for consistent application to skin User Safety • User interface alarms operator when critical temperature is reached • Proximity to skin determined in real-time • Automatic Shut-off System Visible alarms Temperature at wound and distance to wound highly visible Emergency stop button to cut laser power Easy calibration to ensure consistency between trials Visible indication of current laser power Acknowledgments and References 1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9. Special Thanks to: • Andre Gobin • Dr. Jennifer West, Rice University • Dr. Oden, Rice University • CBEN • Brown Foundation Teaching Grant

5. Cut “s” in “Costs” Why report volume in ft3? Re-order based on importance or group by implicit logical categories

6. Don’t justify line spacing because it creates odd spaces between words. Lower case “s”

7. Nice large image to highlight design, but replace with image of device put together. Use callouts for key components. Serif font Explain how it works.

8. What’s the purpose of this section? The text bullets seem to explain the obvious. Use one font consistently.

9. Need to describe testing.

10. Need to report results in more detail. What’s this?

11. These aren’t conclusions. Focus on your design’s features and advantages

12. Use paragraph form to create more space above for testing and results. Capital “N” Spell out CBEN. Italicize journals.

13. Revised poster . . .

14. TEAM LA ER NanoStitch A Nanoshell Assisted Laser Tissue Welding System Team Lazer, Department of Bioengineering, Rice University Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar teamlazer@gmail.com Introduction NanoStitch How it Works User Interface Current methods of wound closure, such as sutures and liquid adhesives, lead to increased scarring, cost, inconvenience, and possibility for infection. A new approach that combines nanoshell technology with laser tissue welding1 appears promising. However, the problem of user variability remains to be solved. Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly software to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin. Set Up • Laser adjusted to desired conditions • Distance and temperature sensor calibrated Sample Preparation • Chicken samples isolated • Nanoshell solder applied directly to wound NanoStitch Concept Prototype Requirements • Easily Portable • Maximum Safety • Cost < $5 per use • Cost < $1500 per device • Operable with minimal training • Highly Consistent & Repeatable • Operator friendly computer interface Safety Feedback Mechanisms • If temperature becomes too high, alarms trigger operator and laser intensity ramped down • Operator notified of distance to wound in real- time to ensure consistency Size of Wound: 2-5cm Volume < 2m³ Sensing Distance: 2-10cm Commence Annealing Process • Laser shined over wound to begin closure • Motor adjusts angle of laser to maintain surface exposure Safe, Successful Wound Closure!! Safety Concerns Addressed Safe and Effective Solution Conclusions Patient Safety • Temperature monitoring prevents damage to skin • Modulated laser intensity to prevent burns • Reduced manipulation of wound  Less opportunity for infection • Motorized angle adjustment allows for consistent application to skin Operator Safety • Alarms when critical temperature is reached • Proximity to skin determined in real-time • Automatic Shut-off system Mechanical tensile failure tests were implemented to determine efficacy of NanoStitch No significant difference between tensile strength of NanoStitch and Suturing Technique (two-sample t-test, a<0.05) NanoStitch exhibits significantly greater Young’s Modulus over Handheld technique (two-sample t-test, a<0.05) Qualitative analysis illustrate more frequent failure at grip site, rather than welding site, during NanoStitch testing NanoStitch goes one step further than conventional hand-held laser tissue welding technology. The incorporation of real-time feedback controlled distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure. Acknowledgments and References 1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9. Special Thanks: Team Lazer would like to thank Andre Gobin, Dr. Jennifer West, Dr. Maria Oden, Joseph Gesenhues, the Center for Biological and Environmental Nanotechnology and the Brown Foundation Teaching Grant for all of their help and support throughout the entire design process.

15. TEAM LA ER NanoStitch A Nanoshell Assisted Laser Tissue Welding System Team Lazer, Department of Bioengineering, Rice University Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar teamlazer@gmail.com Introduction NanoStitch How it Works User Interface Current methods of wound closure, such as sutures and liquid adhesives, lead to increased scarring, cost, inconvenience, and possibility for infection. A new approach that combines nanoshell technology with laser tissue welding1 appears promising. However, the problem of user variability remains to be solved. Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly software to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin. Set Up • Laser adjusted to desired conditions • Distance and temperature sensor calibrated Sample Preparation • Chicken samples isolated • Nanoshell solder applied directly to wound Overall, revised poster contains an appropriate balance of text and visuals. Excellent use of images, text boxes, and arrows to represent the device and how it works. Use of red/blue in this section provides additional coherence. Layout is accessible. Material is comprehensible. Formatting is consistent. NanoStitch Concept Prototype Requirements • Easily Portable • Maximum Safety • Cost < $5 per use • Cost < $1500 per device • Operable with minimal training • Highly Consistent & Repeatable • Operator friendly computer interface Safety Feedback Mechanisms • If temperature becomes too high, alarms trigger operator and laser intensity ramped down • Operator notified of distance to wound in real- time to ensure consistency Size of Wound: 2-5cm Volume < 2m³ Sensing Distance: 2-10cm Commence Annealing Process • Laser shined over wound to begin closure • Motor adjusts angle of laser to maintain surface exposure Safe, Successful Wound Closure!! Safety Concerns Addressed Safe and Effective Solution Conclusions Patient Safety • Temperature monitoring prevents damage to skin • Modulated laser intensity to prevent burns • Reduced manipulation of wound  Less opportunity for infection • Motorized angle adjustment allows for consistent application to skin Operator Safety • Alarms when critical temperature is reached • Proximity to skin determined in real-time • Automatic Shut-off system Mechanical tensile failure tests were implemented to determine efficacy of NanoStitch No significant difference between tensile strength of NanoStitch and Suturing Technique (two-sample t-test, a<0.05) NanoStitch exhibits significantly greater Young’s Modulus over Handheld technique (two-sample t-test, a<0.05) Qualitative analysis illustrate more frequent failure at grip site, rather than welding site, during NanoStitch testing NanoStitch goes one step further than conventional hand-held laser tissue welding technology. The incorporation of real-time feedback controlled distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure. Acknowledgments and References 1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9. Special Thanks: Team Lazer would like to thank Andre Gobin, Dr. Jennifer West, Dr. Maria Oden, Joseph Gesenhues, the Center for Biological and Environmental Nanotechnology and the Brown Foundation Teaching Grant for all of their help and support throughout the entire design process.