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SALISBURY 20 th February 2008. Allicin - Nature’s Antibiotic. From the heart of garlic. What’s in garlic that makes it so powerful?. Garlic contains a wide range of vitamins and minerals a sulphur compound called “alliin” and an enzyme called “alliinase”
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SALISBURY 20th February 2008 Allicin - Nature’s Antibiotic From the heart of garlic
What’s in garlic that makes it so powerful? • Garlic contains a wide range of vitamins and minerals a sulphur compound called “alliin” and an enzyme called “alliinase” • When harvested garlic has no smell but it contains a very potent defence mechanism that starts when garlic is cut, cooked, boiled, chopped, fried or mechanically processed in any way
Now for the smelly bit! Let’s make some Allicin Crush some fresh garlic
Allicin the “Mother” substance THIOSULPHINATE COMPOUNDS FORMED WHEN ALLICIN BREAKS DOWN ARE ALSO BODY ACTIVE
Historical properties of garlic that can be attributed to allicin • Anti-bacterial - wide spectrum of sensitive bacteria both gram positive and negative • Anti-viral (including common cold virus) • Anti-fungal (more effective than many drugs) • Anti-cancer (IOWA women’s study) • Anti-cholesterol (substantial data) • Anti-blood pressure (substantial data) • May reduce blood sugar levels • May help to reduce fat build up and lead to loss of weight
Types of Garlic supplement • Garlic oil capsules – no allicin potential • Aged garlic extract – no allicin potential • Garlic macerates – some allicin potential? • Garlic powder – potential depends on processing • Garlic powder easily inactivated by stomach acid • Allicin powder supplements like AllicinMax have now been available for 7 years
Active supplement manufactured by Allicin International Limited
Preventing the Common Cold A double blind placebo controlled survey with 146 volunteers
Antiviral: How “common” is a cold? • In the Western World we see 2-5 coldson average per person per year • Over 200 different cold virus types • Viral disease is an excellent traveller • The common cold costs National economies enormous sums of money in lost working days • Prevention is always better than cure
Active supplement with the optimum dose of allicin is found ONLY in AllicinMax
Results - Number of colds P<0.05
Repeat infections p<0.001
Conclusions • AllicinMax can prevent the Common Cold • Reduction of severity of symptoms • Re-infection less likely with AllicinMax • Could represent huge savings for the UK economy • Product is well tolerated and may offer other advantages according to volunteer reports • Manufacturer’s recommended dose was used • Addition of various vitamins or minerals or herbs is a logical combination
Allicin as a modern anti-bacterial • Known as “Nature’s antibiotic” • Broad spectrum of activity • No resistance has ever been recorded • Allicin prevents bacterial enzyme production • Problem infections can be resolved with allicin • Allicin is natural, safe and effective
MIC (ppm allicin) for some problem bacteria • Streptococcus pyogenes 16 ppm • Staphylococcus aureus 16 ppm • Listeria monocytogenes 16 ppm • Escherichia coli 0157 32 ppm • Salmonella typhimurium 32 ppm • Clostridium perfringens 64 ppm • Helicobacter pylori 16 ppm
Staphylococcus aureus • Involved in 95% of simple cases of eczema • Leads to worsening of clinical symptoms • Causes secondary infection • Prevents topical steroids from working • Present in most cases of acne • Prevalant bacterium in psoriasis
Where it all began with real patients Debra’s wounds - open on the right but after treatment on the left both long standing wounds had closed and no further procedures were required
Allicin kills Staph. aureus • Work completed at The University of East London • 30 bacterial strains were tested 12 were resistant to pharmaceutical antibiotics • ALL strains were sensitive to Allicin • Published in June 2004 in The Journal of Biomedical Science
AllicinMax vs MUPIROCIN (a pharmaceutical antibiotic)
Case history – before treatment • Female, 14 yrs old 2 pins inserted wounds failed to heal for 18 months. Patient had several courses of antibiotics with no effect. Surgeons were keen to readmit her and replace the pins and deal with the infection. We tested her as ++MRSA sensitive to allicin
Case history after treatment • Treatment was 1800 mg of allicin powder daily in divided doses (AllicinMAX only) for a period of 4 weeks. No creams or spray were needed in this case. Swabs post treatment showed no MRSA infection present in the healed area, groin or nasal cavity
Is allicin really stable? Shelf-life
CH CH 2 2 CH CH 2 2 Mass Spectrometric Analysis of Allicin Allicin 1 mg/ml (Lawson) O 163 (M+H+) 100 CH S S CH Allicin (162) 75 Mass Intensity 73 40,128 121 54,038 163 162,051 Relative Intensity (%) 50 121 73 25 180 (M+NH4+) 0 100 150 200 250 300 350 400 m/z
Summary • A unique opportunity to capitalise on the long established properties of garlic’s active mother substance ALLICIN. Only now is this 21st century molecule available in a form that the human race can really feel the benefit. Antiviral, Antibacterial, Antifungal, Antihistamine Antiparasite, Anticholesterol, Antihypertensive