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Antibiotic Resistance

Antibiotic Resistance. Do Now: Copy the following definitions: Antibiotic : a chemical that kills bacteria. Antibiotic resistance : the ability of some bacteria to survive exposure to antibiotics that are usually lethal to it.

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Antibiotic Resistance

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  1. Antibiotic Resistance Do Now: Copy the following definitions: Antibiotic: a chemical that kills bacteria. Antibiotic resistance: the ability of some bacteria to survive exposure to antibiotics that are usually lethal to it. Plasmid: A small piece of bacterial DNA that may carry resistance genes

  2. Antibiotics • Antibiotics were first discovered in the mid 20th century, and used to fight common bacterial diseases. • Antibiotics originate from soil organisms (go Waksman!)

  3. How they work • Many antibiotics work by destroying the cell walls of bacteria

  4. Video Presentations • The video we will watch uses TB as an example of how drug resistance can develop in a population. • Remember, the principle of selection for resistance can be applied to any bacteria. • Eye of Nye 109: 5:51

  5. You are a bacterium • Each of you represents one bacterial cell infecting the lungs of a new TB victim. • The circles in the envelopes represent the different antibiotic resistance genes you have. • The sick patient is about to receive antibiotics…

  6. Round 1: Penicillin • The first thing the doctors try to kill you with is penicillin. • If you have 1 or more penicillin resistance plasmids, stand up. • Record data

  7. Round 2: Vancomycin • The bacteria that are resistant divide (come get new envelopes if I tell you) • Seeing that the patient is still ill, the doctor prescribes Vancomycin along with penicillin. • If you have a Vancomycin resistance plasmid AND a penicillin resistance plasmid, remain standing.

  8. Results • What did the presence of antibiotics do? • How is the term “selection” appropriate?

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