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Wnt/β-catenin pathway

Wnt/β-catenin pathway. Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man. Wnt pathway. Ligands Receptors Intracellular components Transcription factors Interactome. Wnt. “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes

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Wnt/β-catenin pathway

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  1. Wnt/β-catenin pathway • Seminar Spring 2011 • Maneeshi Prasad • 21st Jan 2011 • Man

  2. Wnt pathway • Ligands • Receptors • Intracellular components • Transcription factors • Interactome

  3. Wnt • “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes • Wnt are secreted proteins • 19 Wnt genes in humans and mice

  4. Wnt Receptors • Receptor tyrosine kinase • Derailed/RYK • ROR • Frizzled-transmembrane receptor • LRP (lipoprotein-receptor related protein) • Single-pass Tm proteins • Cytoplasmic tail phosphorylated by GSK3 and CK1γ http://www.stanford.edu/group/nusselab/cgi-bin/wnt/main#Diagrams

  5. Wnt Pathway

  6. Wnt signaling

  7. Interactions: Intracellular Components

  8. Intracellular Components

  9. Canonical/Non-canonical Wnt pathway

  10. Wnt Pathway Interactome

  11. Wnt pathway interactions

  12. Role of Wnt signaling

  13. Role of Wnt signaling • Development • Neural development: CNS • Neural crest • Limb • Tumor formation • Cellular growth and proliferation

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