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Murein Biosynthesis Tutorial

Murein Biosynthesis Tutorial. by. Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001. NAG. UDP. NAM. UDP. Legend. Uridine Diphosphate-N-Acetyl Glucosamine. Uridine Diphosphate-N-Acetylmuramic Acid. L-Alanine. D-Glutamic Acid.

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Murein Biosynthesis Tutorial

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  1. Murein Biosynthesis Tutorial by Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001

  2. NAG UDP NAM UDP Legend Uridine Diphosphate-N-Acetyl Glucosamine Uridine Diphosphate-N-Acetylmuramic Acid L-Alanine D-Glutamic Acid Dibasic Amino Acid D-Alanine D-Alanine Tri-Alanine Peptide Bactoprenol Carrier Lipid-Derivative of a C-55 Polyisoprenoid Alcohol

  3. Formation of Amino Sugars NAG UDP NAM UDP Fructose-6-P Glutamine(NH2) Acetyl CoA N-Acetylglucosamine(NAG) UTP P Phosphoenol Pyruvate(Lactyl) Reduction Steps Other Cell Reactions Murein Biosynthesis

  4. Sequence of Events inMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol NAM NAM Bactoprenol NAM NAM P-P Bactoprenol P-P NAM UDP NAM D-ala-D-ala 6 5 L-ala ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 P 8 13 Membrane 10 Section of Growing Murein 11 12 14 [Crosslinking Step] Exterior

  5. Sequence of Events inMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 8 13 Membrane 10 11 12 14 Exterior [Crosslinking Step]

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