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Calculation Examples

Calculation Examples. Convert various volumes to number of drops. Droplet Sizes. This seems to have caused a lot of confusion The reason that it is necessary to be able to convert number of drops to millilitres and visa versa if purely for convenience.

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Calculation Examples

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  1. Calculation Examples Convert various volumes to number of drops

  2. Droplet Sizes This seems to have caused a lot of confusion The reason that it is necessary to be able to convert number of drops to millilitres and visa versa if purely for convenience. Compared to a drop of distilled water, increased concentrations of alcohol have a decreased volume. In other words, the size of one drop on 96% alcohol is significantly smaller that the size of one drop of 20% alcohol. For accuracy when taking remedies up in potency it is necessary to ensure that the ratio is correct. If you are for example: You have a 4X on your shelf in 86% alcohol and you want to take it up a potency to 5X in 73% alcohol. You can not simply add 10 drops of 86% to 90drops of 73% as the droplet sizes are different and the ratio wil no longer be 1 to 9. It is therefor necessary to always compare “apples with apples” (as my teacher used to say) when working with droplets of different alcohol concentrations

  3. Droplets • It is important to note that if you are working in millilitres and not droplets, this calculation is not necessary because 1ml of 73% R-OH is the same volume as 1ml of 86% R-OH. You are comparing apples with apples if both substances are measured in millilitres: • Example: If you have 4X in 86% R-OH and you want to take it up to 5X in 73% R-OH: If you measure 1ml of 4X you can add it to 9ml of 73% alcohol and the ration of 1:9 remains correct as you are comparing millilitres to millilitres.

  4. Example 1 • If you are simply taking a remedy up a potency to create a potency bank and you do not require a specific volume of the final potency: For example: • If you have a 4X in 96% R-OH and you want to take it up to a 5X in 73% R-OH to medicate powders – you do not need a specific volume:

  5. Example 1 The ratio for decimal potencies is 1:9 You need 1 drop of 4X (in 96%) to ? Drops of 73% alcohol that makes it equivalent to 9 drops of 96% If you look at the table provided in the manual: 38 drops (gtt) in 1ml 96% compared to 35 drops in 1ml of 73% This means that the droplet size f 96% is 38/35 = 1.09 times smaller than the droplet size of 73% In order to keep the ration correct you could either: Say 1 drop x 1.09 = 2 drops of 96 added to 9 drops of 73% would keep ratio correct Or 1 drop 96% added to 9/1.09 = 8.3 drops or round off to 8 drops to keep ratio correct

  6. Example 2 If you have a 6cH in 96% R-OH and you want to take it up a potency in 60% R-OH 1 drop 6cH to 99 drops of 60% 38 drops per ml in 96% and 33 drops per ml of 60% This means that one drop of 96% is 38/33 = 1.15 times smaller than one drop of 60% 1 drop of 6cH in 96% needs to be added to 99/1.15 = 86 drops of 60% R-OH to keep the ratio correct. In other words 86 drops of 60% R-OH is roughly equal in volume to 99 drops of 96% R-OH

  7. Example 3 When requiring a specific final volume it is often convenient to convert ml to number of drops, Eg: If you have 6cH in 96% R-OH and you want to dispense 20ml of 7cH in 20% R-OH: You need 1ml of 6cH to 99ml of 20% R-OH You only want 20ml ….. So……….(divide required volume by 100) you need 0.2ml of 6cH to 19.8ml of 20% R-OH you are comparing ml to ml so you do not need to convert droplet sizes but measuring 0.2ml may be inconvenient……….so………. You can convert 0.2ml of 6cH in 96% R-OH to number of drops on 0.2ml …… using the table in the manual: 38 drops in 1ml of 96% R-OH so in 0.2ml there is: 38 x 0.2 = 7.6 drops rounded off to 8 drops You can put 8 drops of 6cH (96%) into 19.8ml of 20% R-OH and you will have 20ml of 7cH in 20% alcohol!!!

  8. Example 4 Another example where this conversion may be convenient is when medicating a solid dosage form: Example: If you want to medicate 100ml of lactose granules with a medicating remedy of 12X in 96% alcohol: To medicate granules you know that you need 1% volume to volume: 1% of 100ml = 1ml To do triple impregnation of granules, it is more convenient to work with drops instead of millilitres: You need 1ml of medicating potency. It is in 96% R-OH. According to the table in the manual, there are 38 drops of 96% in 1ml – so we need 38 drops of our medicating potency: For triple impregnation divide number of drops by three: 12 + 13+ 13 = 38 drops

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