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Chapter 81. Drugs That Weaken the Bacterial Cell Wall II: Cephalosporins, Carbapenems, Aztreonam, Vancomycin, Teicoplanin, and Fosfomycin. Cephalosporins. Most widely used group of antibiotics Beta-lactam antibiotics Similar to penicillin structure Bactericidal Usually given parenterally
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Chapter 81 Drugs That Weakenthe Bacterial Cell Wall II:Cephalosporins, Carbapenems, Aztreonam, Vancomycin, Teicoplanin, and Fosfomycin
Cephalosporins • Most widely used group of antibiotics • Beta-lactam antibiotics • Similar to penicillin structure • Bactericidal • Usually given parenterally • Adverse effects • Allergy • Bleeding • Thrombophlebitis
Classification of Cephalosporins • First generation • Cefazolin (Ancef) • Second generation • Cefaclor (Ceclor) • Third generation • Cefoperazone (Cefobid) • Fourth generation • Cefepime (Maxipime)
Vancomycin (Lyphocin) • Action • Cell wall synthesis • Uses • Severe infections • Methicillin-resistant Staphylococcus aureus or Staph • Adverse effects • Ototoxicity • Thrombophlebitis • Allergy