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Metabolism in Skeletal Muscle

Metabolism in Skeletal Muscle. Eric Niederhoffer SIU-SOM. Glycolysis Glycogenolysis  -oxidation (ketone bodies) Krebs (tricarboxylic acid) cycle Branched-chain amino acids Electron transport chain Calcium regulation Key enzyme regulation. Ketone bodies. Glucose. Glycogen. Glycolysis.

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Metabolism in Skeletal Muscle

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  1. Metabolism in Skeletal Muscle Eric Niederhoffer SIU-SOM • Glycolysis • Glycogenolysis • -oxidation (ketone bodies) • Krebs (tricarboxylic acid) cycle • Branched-chain amino acids • Electron transport chain • Calcium regulation • Key enzyme regulation

  2. Ketone bodies Glucose Glycogen Glycolysis Fatty acids Glycogenolysis b-Oxidation Ca2+ PKa Ca2+ PDH No O2 Lactate Pyruvate Acetyl-CoA Electron Transport Chain Krebs cycle BCAA Ile, Leu, Val Ca2+ ISDH, aKGDH Pathways Overview G6P Production of ATP

  3. Ep AR ATP Citrate AC cAMP ATP G6P PKA Ca2+ PKa F6P PFK-2 PP F26BP Pi IMP AMP NH4+ AMP Pi F16BP PEP PDHP Ca2+ PDHP PDHK Pyr Acetyl-CoA PDH Regulation in Skeletal Muscle Glc Glycolysis PFK-1 Glycogen Glycogenolysis b-Oxidation Fatty acids PK PDH

  4. Review Questions • How does muscle produce ATP (carbohydrates, fatty acids, ketone bodies, branched-chain amino acids)? • How is skeletal muscle phosphofructokinase-1 regulated? • What are the key Ca2+ regulated steps?

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