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Perceiving invisible light through a somatosensory cortical prosthesis

Perceiving invisible light through a somatosensory cortical prosthesis. Eric E. Thompson, Rafael Carra , Miguel A.L. Nicolelis Presented by: Anil S ishta. Why is this research important?. Some cases require augmentation rather than restoration (plasticity)

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Perceiving invisible light through a somatosensory cortical prosthesis

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  1. Perceiving invisible light through a somatosensory cortical prosthesis Eric E. Thompson, Rafael Carra, Miguel A.L. Nicolelis Presented by: Anil Sishta

  2. Why is this research important? • Some cases require augmentation rather than restoration (plasticity) • Some success with neuroprostheses in younger mammals only (ferrets) • Lead to developments in human medicine • Restoration of hearing/visual loss • New motor neuroprostheses

  3. Methods Trained rats to receive water with visible light first Then surgically affixed IR receptor to S1 cortex and conducted similar tests

  4. Methods continued Required 70% correct for >4 consecutive days as criterion Experimented with difficulty by varying the angle between the ports Would measure time to reach criterion, latency, and difficulty After surgery, showed both IR and visible light to rats to create a desired response

  5. Results 130 sessions in 4 rats 66 sessions in 2 rats 100 sessions in 2 rats

  6. Results • Average 93% correct • Latency dropped from initially 2.3s to 1.3s • Experimental Design Test • Turned IR light on without stimulation • Yielded 8%, below random 33% since most rats did not poke into ports at all

  7. Results • Behavioral Changes • Quickly learned to scan for stimuli • Latency decreases • Also showed sensitivity to graded IR signals rather than constant stimuli • On average, 85% of neurons maintained the whisker deflection ability

  8. Discussion • First cortical neuroprosthesis capable of expanding the host’s perceptual repertoire • Future Research • Mechanisms on how animals learn to use this new information source/sense • More research into plasticity • Unable to determine if fully trained rats experienced micro stimulation as a new sensory input or if simply learned to associate the tactile sensation with water reward

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