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Supplementary Figure 1. Sequence alignment of RNase Z and COGs of the metallo -lactamase family. Families are as follows: pfam00753, Lactamase-, Metallo--lactamase superfamily; COG0491, GloB, Zn-dependent hydrolases, including glyoxylases; COG0595, Predicted hydrolase of the metallo--lactamase superfamily; COG1237, Metal-dependent hydrolases of the -lactamase superfamily II; COG1236, YSH1, Predicted exonuclease of the -lactamase fold involved in RNA processing; COG1235, PhnP, Metal-dependent hydrolases of the -lactamase superfamily I; COG1234, ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III.