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Cephalosporins. Treatment of a wide range of bacteria including those sensitive to penicillin. 4 Groupings First Generation to Fourth Generation Increase sensitivity to gram negative decrease gram positive. . Cephalosporins. Actions Affect cell wall Typically bactericidal
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Cephalosporins • Treatment of a wide range of bacteria including those sensitive to penicillin. • 4 Groupings • First Generation to Fourth Generation • Increase sensitivity to gram negative decrease gram positive. Dr. Steven I. Dworkin
Cephalosporins • Actions • Affect cell wall • Typically bactericidal • Adverse reactions • Gastrointestinal disturbances • Hypersensitivity • Headache, dizziness, nephrotoxicity, malaise, fever • Bacteria or fungal superinfection Dr. Steven I. Dworkin
Broad-Spectrum Antibiotics • Tetracyclines, Macrolides, and Lincosamides • Tetracyclines • Anti-infectives natural and synthetic compounds • Treatment of cholera, Rocky Mountain spotted fever. • May cause permanent discoloration of teeth children under 9. • Macrolides • Effective against a wide variety of pathogenic organisms especially infections of respiratory and genital tracts. • Treatment of gram-negative and positive organisms. Dr. Steven I. Dworkin
Broad-Spectrum Antibiotics • Tetracyclines, Macrolides, and Lincosamides • Lincosamides • Anti-infectives effective against gram-positive and gram-negative bacteria (streptococci and staphylococci). • High potential for toxicity limits use. Dr. Steven I. Dworkin