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Welcome Doherty Memorial High School

Welcome Doherty Memorial High School. Genzyme Center November 1, 2012. Our mission is to discover and deliver transformative therapies for patients with rare and special unmet medical needs, providing hope where there was none before. Jannan Multiple Sclerosis USA. 2. About Genzyme.

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Welcome Doherty Memorial High School

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  1. Welcome Doherty Memorial High School Genzyme Center November 1, 2012

  2. Our mission is to discover and deliver transformative therapies for patients with rare and special unmet medical needs, providing hope where there was none before. Jannan Multiple Sclerosis USA 2

  3. About Genzyme Focused on rare diseases andmultiple sclerosis (MS) 6 major marketed products 10,000 employees worldwide Founded in 1981 and pioneered treatments for rare diseases David Meeker, MD, CEO 3

  4. Our Global Commitment Serving patients in over 100 countries Headquarteredin the U.S.with global locationsin over 40 countries Expanding manufacturing capabilities in the U.S. and E.U. Collaborating with patient communities, physicians, universities, hospitals, charitable organizations, companies globally 4

  5. Genzyme, a Sanofi company In April 2011, Genzyme became a wholly owned subsidiary of Sanofi We benefit from the reach and resources of one of the world’s largest pharmaceutical companies Sanofi’s portfolio of products includes: prescription medicines, vaccines, generics, consumer health care, and animal health 110,000 employees worldwide 5

  6. Patients are at the heart of what we do Science Sales & marketing Manufacturing & Distribution Legal, HR, Communications Government Affairs Advocacy & Access Regulatory 6

  7. AnisaMPS I disease JoanThyroid Cancer Eulacio Children Gaucher disease ThomasFH MelanieMultiple Sclerosis FidaPompedisease AveryFabry disease

  8. A lifetime commitment “My mom was just tremendous and an amazing role model for me. I know the doctors told her that I was going to die but her perseverance, dedication and ability to work closely with Genzyme and search around the world to develop a treatment was amazing.” – Brian Berman, Gaucher disease type 1 1983 1991 2001 2011 8

  9. Genzyme’s Business Units Rare Diseases Multiple Sclerosis Genetic Diseases Gaucher disease type 1, Fabry disease, Pompe disease, MPS I disease Endocrinology Facilitating thyroid cancertreatment and testing One oral marketed product and One late-stage infusion treatment Cardiovascular Late-stage treatment for Familial Hypercholesterolemia (FH) 9

  10. Driven by Science • Genzyme R&D Center • Broad range of technology platforms • Closely integrated with clinical, commercial, regulatory, patient advocacy • Dedicated to pursuing unmet medical needs • Highlights • Research in Parkinson’s, Niemann-Pick, Lupus, and Cystic Fibrosis • Next-generation therapies for Gaucher, Pompe, and Fabry diseases 10

  11. Our Responsibility Community Involvement: Employee volunteerism, support for science education and health initiatives Humanitarian Programs:Free drug programs Environmental Initiatives:Green buildings and greenhouse gas reduction efforts School Science Program Waterford, Ireland 11

  12. Genzyme Center - Today How did we get here and why?

  13. Genzyme: The Beginning - 1981 Kneeland Street, Boston A company that cares about • Patients • Employees

  14. One Kendall Square Cambridge, MA Genzyme’s Headquarters 1990-2003

  15. A Brownfield site is an industrial site that has ground contamination plant that turned coal into gas (a coal gasification plant) Developer bought 10 acre site for $21 million Cost to remediate site from contaminants - $198 million Brownfield Site - Cambridge, MA

  16. Remediation of Brownfield Site

  17. Committed to the Community 1925 2000 2003

  18. Anchor of Mixed Use Development

  19. Considerations for New World Headquarters • Location • Size • Cost • Comfort of Employees • Recruitment & Retention • The Environment • Building Materials • Company Culture

  20. Drive Entrepreneurialism Innovation Integrity Collaboration Compassion Reflecting Corporate Values in the Building Core Values - INNOVATION COLLABORATION TRANSPARENCY

  21. The Concept of Genzyme Center • Reflective of Genzyme’s core values • Designed from the inside out • Productive and collaborative workspace • Environmentally responsible and energy-efficient

  22. United States Green Building Council • Genzyme Center received Platinum LEED rating • Leadership in Energy & Environmental Design • The highest rating of the United States Green Building Council • Rating is based on: • Sustainable site design • Materials selection • Energy use • Water conservation • Indoor environmental quality

  23. Site Selection, Design & Indoor Environmental Quality • Restored Brownfield site • Living roof: heat reduction, rainwater run-off reduction • White roof to reduce “heat island effect” • Direct view of the outdoors from 90% of work spaces • 18 themed interior gardens

  24. Material Selection • Recycled 93% of construction waste • 23% of materials used in building are recycled material (concrete, steel, aluminum, tile, drywall, ceilings, carpets) • More than 60% materials from local sources • Wood materials from managed forests • Recycled content carpet squares • Concrete filigree slab construction

  25. Energy-Efficient Features • Concrete slab construction • Insulating “loggia” • 800+ operable windows • Solar panels • Produce 1% of Genzyme Center’s electricity • Waste steam used for heating and cooling, efficient systems, building control, use of natural ventilation • Use of “green” power from renewable source

  26. Water Conservation • High efficiency irrigation using soil sensors • Rainwater run-off collection systems • Low flow fixtures – waterless urinals, dual flush toilets • 525,000 gallons per year saved • Lobby floor water feature / reflecting pool

  27. Natural Light Enhancement Systems

  28. Natural Light Enhancement Systems • Soaring 12-story atrium

  29. Natural Light Enhancement Systems • All glass exterior • Heliostats on roof

  30. Natural Light Enhancement Systems • Skylight and louvered sunshades

  31. Natural Light Enhancement Systems • Chandelier • Prismatic tiles

  32. Natural Light Enhancement Systems • “Light wall” of polished aluminum strips • Reflecting pool

  33. Natural Light Enhancement Systems • Computer controlled blinds • Reflective Ceiling Panels

  34. Ceiling Design • Inspired by Matisse’s Blue Nude

  35. Ceiling Design

  36. Genzyme Green Buildings - LEED Registered and Certified 2005: Genzyme Center: NC: Platinum 2007: 675 West Kendall: CI: Silver 2008: Framingham Science Center: NC: Gold 2009: Ridgefield: NC: Gold 2010: Lyon: HQE Certified (and LEED) 2010: Phoenix: CI: Silver 2010: Allston: NC Gold 2010: Waterford: NC Gold 2010: San Antonio: EB Silver 2011: Ridgefield: CI: Platinum 31 New York Avenue 68 New York Avenue Northborough Distribution Center Geel, Belgium Framingham Science Center, 49 New York Avenue LEED NC: new construction CI: commercial interior EB: existing building HQE: High Environmental Quality (French Standard) Lyon, France Manufacturing Plant

  37. Questions? Thank You

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