1 / 17

Hyperpolarized MRI Imaging

Hyperpolarized MRI Imaging. By Bilal Badr. Outline. Hyperpolarization 13 Carbon Polarization Method Results Discussion Conclusion. Hyperpolarization. Offer unique advantage in improving SNR Goal of Hyperpolarization is to increase nuclear spin alignment

domingob
Download Presentation

Hyperpolarized MRI Imaging

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Hyperpolarized MRIImaging By BilalBadr

  2. Outline • Hyperpolarization • 13Carbon Polarization • Method • Results • Discussion • Conclusion www.coreorthopeadic.com

  3. Hyperpolarization • Offer unique advantage in improving SNR • Goal of Hyperpolarization is to increase nuclear spin alignment • Uses inert gases ( 129Xe , 3He) or 13Carbon • Utilize low-γ for longer T1 relaxation • Correspond to signal enhancement ~ 10,000 Eduard Chekmenev et. al. Development of Contrast Agents

  4. 1H Magnetic Resonance Spectroscopy • Typically proton used • Has been found to be useful in observing metabolites in vivo • Disadvantage: Most of signal observed comes from water and fat which masks signals from more interesting metabolites.

  5. 13Carbon Hyperpolarization • Only 1.1% of carbons in metabolites are 13C –nuclei • Enrich specific molecule with 13C • Applications include: • Angiography • Cellular metabolism www.dpag.ox.ac.uk/research/damian_tyler

  6. 13Carbon Hyperpolarization Jan Henrik et. al. Method for making Hyperpolarized nuclear spins

  7. 13Carbon Hyperpolarization Jan Henrik et. al. Method for making Hyperpolarized nuclear spins

  8. 13Carbon HyperpolarizationMotivation • Studied effects of Prohance • Contains Gadolinium • Shortens T1 of electron in radical and 13C • Increases the amount of polarization • Increases time to reach maximum polarization www.ennislaw.com/gadolinium .html

  9. Ideal result where polarization time reduced as much as possible and T1 is as maximum as possible Objective

  10. Pyruvic Acid + OX63 Add Prohance Hyperpolarizer B0 = 3.35T T = 1.4K Measure T1 Relaxation Methods Jan Henrik et. al. Method for making Hyperpolarized nuclear spins

  11. Results

  12. Results

  13. Results

  14. Results

  15. Discussion

  16. Conclusion In general, the best balance for reducing polarization time and maintaining good T1 signal is 1.0 mM of Prohance

  17. Questions ?

More Related