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Small Animal Ventilator for Hyperpolarized Helium MRI

Small Animal Ventilator for Hyperpolarized Helium MRI. Ashley Anderson III, Micah Brown, Matt Smith, Chris Wegener Client: Dr. Sean Fain Advisor: Dr. Willis Tompkins. Client Requirements. MRI compatible ventilator system Deliver 20% O2 and 80% He-3 in same breath

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Small Animal Ventilator for Hyperpolarized Helium MRI

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  1. Small Animal Ventilator for Hyperpolarized Helium MRI Ashley Anderson III, Micah Brown, Matt Smith, Chris Wegener Client: Dr. Sean Fain Advisor: Dr. Willis Tompkins

  2. Client Requirements • MRI compatible ventilator system • Deliver 20% O2 and 80% He-3 in same breath • Allows constant scanning of the He-3 in MRI rather than every 4 breaths

  3. Background - Helium MRI • Newer technique • Same MRI scanner • Convention is H • Here, tuned to Helium (48.6 MHz) • Breath of Helium • Displays respiratory channels

  4. Project Concept • Each syringe feeds off of independent gas reservoirs • Gas mixing occurs right before entering small animal

  5. First Generation Prototype • Currently in use in animal studies • Only using one syringe • Not compatible with small syringes for mouse studies

  6. Modifications to G1 • Reinforced syringe clips • Larger motor • Eliminated O2 chaser breath

  7. Calibration Results using manometer testing. Graph shows small deviation from entered volumes.

  8. Second Generation Concept

  9. Second Generation Prototype • Created in Solidworks • Smaller components • Interchangeable syringes • Adjustable axle support

  10. Second Generation Prototype • Large motor • Motor shielding • Precision machining • Can be disassembled

  11. From Solidworks to Reality

  12. Does it move?

  13. Did we meet client requirements? • Gear ratios allow the appropriate 80/20 gas output ratio • MRI Safe materials • Motor shielded for RF • Rat/Mouse compatible

  14. Future Work • Calibration testing • Volume delivery • Timing • Software development • Simultaneous 3He/O2 delivery • Inspired time based on %Insp and RR • Valve switching • Mixing testing (imaging)

  15. Questions?

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