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Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

LDLR/Apobec-1–DKO mice were given 3 dosages of human CETP (hCETP), adeno-associated virus serotype 8 (AAV8), or LacZ via intraperitoneal injection (n5/each group)

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Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

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  1. LDLR/Apobec-1–DKO mice were given 3 dosages of human CETP (hCETP), adeno-associated virus serotype 8 (AAV8), or LacZ via intraperitoneal injection (n5/each group) A, The change of plasma hCETP mass level of each time point determined by ELISA B, The change of plasma HDL expression level of each time point determined on a Cobas Fara Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

  2. Macrophage RCT in apobec-1–KO mice injected with hCETP, AAV8, or LacZ as a control (n6/each group) A, The change of 3H-labeled cholesterol in plasma. B, 3H-labeled cholesterol lipoprotein profile of pooled plasma samples drawn 48 hours after injection of J774 cells. C, Cholesterol mass profile of pooled plasma samples drawn 48 hours after injection of J774 cells. Mice received intraperitoneal injections of 11011 GC hCETP, AAV8, or LacZ and then 26 days later received intraperitoneal injections of 3H-labeled cholesterol J774 foam cells Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

  3. Macrophage RCT in apobec-1–KO mice injected with hCETP, AAV8, or LacZ as a control (n6/each group) A, 3H-labeled cholesterol in liver of each group. B, 3H-labeled cholesterol in bile of each group. C, 3H-labeled cholesterol in feces of each group. Mice received intraperitoneal injections of 11011 GC hCETP, AAV8, or LacZ and then 26 days later received intraperitoneal injections of 3H-labeled cholesterol J774 foam cells Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

  4. Macrophage RCT in LDLR/apobec-1–DKO mice injected with hCETP, AAV8, or LacZ as a control (n6/each group) A, The change of 3H-labeled cholesterol in plasma. B, 3H-labeled cholesterol lipoprotein profile of pooled plasma samples drawn 48 hours after injection of J774 cells. C, Cholesterol mass profile of pooled plasma samples drawn 48 hours after injection of J774 cells. Mice received intraperitoneal injections of 11011 GC hCETP, AAV8, or LacZ and then 26 days later received intraperitoneal injections of 3H-labeled cholesterol J774 foam cells Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

  5. Macrophage RCT in LDLR/apobec-1–DKO mice injected with hCETP, AAV8, or LacZ as a control (n6/each group) A, 3H-labeled cholesterol in liver of each group. B, 3H-labeled cholesterol in bile of each group. C, 3H-labeled cholesterol in feces of each group. Mice received intraperitoneal injections of 11011 GC hCETP, AAV8, or LacZ and then 26 days later received intraperitoneal injections of 3H-labeled cholesterol J774 foam cells Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

  6. Macrophage RCT in SR-B1–KO mice injected with hCETP, AAV8, or LacZ as a control (n6/each group) A, The change of 3H-labeled cholesterol in plasma. B, 3H-labeled cholesterol lipoprotein profile of pooled plasma samples drawn 48 hours after injection of J774 cells. C, Cholesterol mass profile of pooled plasma samples drawn 48 hours after injection of J774 cells. Mice received intraperitoneal injections of 11011 GC hCETP, AAV8, or LacZ and then 26 days later received intraperitoneal injections of 3H-labeled cholesterol J774 foam cells Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

  7. Macrophage RCT in SR-B1–KO mice injected with hCETP, AAV8, or LacZ as a control (n6/each group) A, 3H-labeled cholesterol in liver of each group. B, 3H-labeled cholesterol in feces of each group Mice received intraperitoneal injections of 11011 GC hCETP, AAV8, or LacZ and then 26 days later received intraperitoneal injections of 3H-labeled cholesterol J774 foam cells Hiroyuki Tanigawa et al. Circulation 2007;116:1267-1273

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