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Antifungal Agents

Antifungal Agents. Infections. Mycosis – any disease produced by a fungus Systemic fungal infections occur much less frequently than S uperficial fungal infections, but are considerably more dangerous. Systemic Fungal Infections. Amphotericin B (Fungizone).

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Antifungal Agents

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  1. Antifungal Agents

  2. Infections • Mycosis – any disease produced by a fungus • Systemic fungal infections occur much less frequently than Superficial fungal infections, but are considerably more dangerous

  3. Systemic Fungal Infections

  4. Amphotericin B (Fungizone) • Dangerous drug, but drug of choice for most systemic fungal infections • May be used topically, but almost always IV • Many serious side effects (renal impairment occurs in approx. 80% clients)

  5. Ketoconazole (Nizoral) • Oral alternative to Amphotericin B • Drugs that reduce gastric acidity, decrease absorption • Most common adverse effects can be reduced by giving with food • Effects on liver are rare, but potentially fatal

  6. Fluconazole (Diflucan) • Half-life of 30 hrs., making once a day dosing possible • Administered oral and IV

  7. Superficial Fungal Infections

  8. Important Facts(Candida species & Dermatophytes) • Candidal infections usually occur in mucous membranes and moist skin • Dermatophytoses generally confined to skin, hair, and nails

  9. Vaginal Candidiasis • Predisposing factors: • Pregnancy • Obesity • Diabetes • Use of oral contraceptives • Systemic glucocorticoids • Systemic antibiotics • Immunosuppressants • Anticancer agents

  10. Superficial Fungal Agents • Clotrimazole (Lotrimin) • Ketoconazole (Nizoral) • Miconazole (Monistat) • Tioconazole (Vagistat) • Griseofulvin

  11. Superficial Fungal Agents • Amphotericin B (Fungizone) • Nystatin (Mycostatin) • Tolnaftate (Tinactin) • Undecylenic Acid (Desenex) • Naftifine (Naftin)

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