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Body composition and physical function in women with multiple sclerosis. Christie L. Ward, MS; Yoojin Suh, MS; Abbi D. Lane, MS; Huimin Yan, MS; Sushant M. Ranadive, PhD; Bo Fernhall, PhD; Robert W. Motl, PhD; Ellen M. Evans, PhD. Aim
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Body composition and physical function in women with multiple sclerosis Christie L. Ward, MS; Yoojin Suh, MS; Abbi D. Lane, MS; Huimin Yan, MS; Sushant M. Ranadive, PhD; Bo Fernhall, PhD;Robert W. Motl, PhD; Ellen M. Evans, PhD
Aim • Determine whether physical activity and body composition were differentially associated with lower-limb physical function in persons with multiple sclerosis (MS) compared with controls. • Relevance • Identifying elements most related to physical functioning for persons with MS may optimize lifestyle choices that prolong independence.
Method • Participants: • Females with MS and controls. • Matched for age and body mass index. • Measures: • Physical activity: daily step counts. • Relative fat mass. • Leg lean mass: dual energy X-ray absorptiometry. • Lower-limb physical function: objective performance tests.
Results • Persons with MS had 12.5% to 53% poorer lower-limb physical function than controls. • Physical activity, relative fat mass, and leg lean mass to body mass ratio associated with lower-limb physical function in both groups. • Median splits: Higher relative fat mass, lower leg lean mass to body mass ratio, and MS conferred poorer lower-limb physical function.
Conclusion • Physical activity, relative fat mass, and leg lean mass to body mass ratio were associated with lower-limb physical function. • Results suggest targeting body composition for MS interventions. • Specifically: reducing adiposity, increasing lean mass, and/or increasing physical activity levels