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Porcine Rhabdomyosarcoma

Porcine Rhabdomyosarcoma. Valerie Cummings, DVM Anatomic Pathology Intern Tuskegee University College of Veterinary Medicine. Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only. Case Presentation.

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Porcine Rhabdomyosarcoma

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  1. Porcine Rhabdomyosarcoma Valerie Cummings, DVM Anatomic Pathology Intern Tuskegee University College of Veterinary Medicine Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  2. Case Presentation • A four week old, Landrace/Yorkshire, male porcine presented for necropsy in February 2006 (n = 120) • Clinical presenting complaint – severe respiratory distress Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  3. Gross Findings • Large mass involving the anterior cervical region • Transverse sectioning  ~ 4 cm x 4 cm x 4 cm, firm, multinodular grayish-white mass attached to C1 and C2 • Infiltration of mass into adjacent skeletal muscle • Lungs – Mild interlobular edema Liver – Focal, 1 mm x 1 mm, grayish white areas (capsular and parenchymal in origin) Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  4. Gross Findings Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  5. Histologic Findings Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  6. Histologic Findings Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  7. Histologic Findings Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  8. Histologic Findings Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  9. Special stain – Mallory’s Phosphotungstic acid hematoxylin (PTAH) Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  10. Immunohistochemistry - Vimentin Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  11. Immunohistochemistry - Alpha sarcomeric actin Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  12. Immunohistochemistry - Myogenin Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

  13. Diagnosis • Embryonal Rhabdomyosarcoma, invasive, porcine Presented at SEVPAC 2007 – Permission granted for use on SEVPAC website only

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