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Comprehensive Guide to Protein Structure & Folds

Explore the diverse world of protein structures, motifs, and folds, including alpha, beta, alpha/beta, and membrane proteins. Learn about structural motifs like Greek Key, β-α-β, and more. Access helpful tools and resources for studying protein biology.

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Comprehensive Guide to Protein Structure & Folds

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  1. Protein Structure Fall 2011 Aaron Zampaglione

  2. Protein Fold Rossmann Fold

  3. Protein Domains (Folds) Four main classes: • All-α • All-β • α+β • α/β • (Membrane and cell surface proteins and peptides) • (Small proteins)

  4. All-α • The lone helix • The helix-turn-helix motif • The four-helix bundle • Helix-helix packing

  5. All-β • β sandwiches and β barrels • Up-and-down antiparallel β sheets • β-propellors • β-trefoils • β-Helix

  6. α+β • Bacterial and mammalian pancreatic ribonucleases • Lysozome • Ubiquitin

  7. α/β • α/βhorseshoe • α/βbarrels beta-alpha-beta

  8. Motif

  9. Structural Motifs • β-α-β • β-hairpin • Greek Key • Helix-Loop-Helix (HLH) • Helix-Turn-Helix (HTH) • Leucine Zipper • Psi-loop • Zinc Finger

  10. β-α-β Motif

  11. β-hairpin Motif

  12. Greek Key Motif

  13. Helix-Loop-Helix (HLH) Motif

  14. Helix-Turn-Helix (HTH) Motif

  15. Leucine Zipper Motif

  16. Psi-loop Motif

  17. Zinc Finger Motif

  18. Biology Workbench • Protein Tools • Alignment Tools • Structure Tools http://workbench.sdsc.edu

  19. Additional Tools • CDART (Motifs) • http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi?cmd=rps • PROSITE (Motifs) • http://prosite.expasy.org/cgi-bin/prosite/prosite-list.pl • SCOP (Structure) • http://scop.mrc-lmb.cam.ac.uk/scop • CATH (Structure) • http://www.cathdb.info

  20. References • Expasy. (1999). Tertiary Protein Structure and folds. Retrieved 08 30, 2011, from Expasy: http://swissmodel.expasy.org/course/text/chapter4.htm • Karadaghi, S. (2011). Protein Domains. Retrieved 08 30, 2011, from Protein Structures: http://www.proteinstructures.com/Structure/Structure/protein-domains.html • …

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