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Understanding Toxicants' Impact on the Cardiovascular System

Explore how toxicants affect the cardiovascular system, including injury mechanisms, blood toxicology, and cardiotoxicants. Learn about cardiac cell types, cardiomyopathy, congenital defects, ECG interpretation, and effects on blood.

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Understanding Toxicants' Impact on the Cardiovascular System

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  1. Toxicology The cardiovascular system

  2. The cardiovascular system • Maintain internal homeostasis. • Regulate body temperature • Maintain tissue and cellular pH.

  3. ChordaeTendineae

  4. Layers of heart

  5. Artery Vein

  6. Cardiac cell type • Cardiac fibroblast • Vascular cells • Purkinje cells • Connective tissue cells • Cardiac myocytes

  7. Cardiomypathy

  8. Cardiomypathy Peripartum Cardiomyopathy Alcoholic Cardiomyopathy

  9. Septal Defect: A Hole in the Heart's Wall

  10. foramen ovalePatent DuctusArteriosus

  11. Electrocardiogram (ECG)

  12. Interpreting ECG

  13. Effects of toxicants on the cardiovascular system There are several different injury mechanism associated with cardiac toxicants. • Generation of free redicals • Lipid peroxidation • Impaired membrane integrity • Mitochondrial dysfunction • Sarcoplasmic reticulum dysfunction • Altered calcium homeostasis

  14. Cardiotoxicants and the associated injuries

  15. Blood toxicology • Direct and indirect damage to the hematopoietic system may produce hypoxia, hemorrhage, infection and death. • Primary hematotoxicity • Secondary hematotoxicity

  16. Toxicants-induced effects on blood

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