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PEDv Pork Management Conference

PEDv Pork Management Conference. June 19, 2014 Carthage Veterinary Service, Ltd. alower@hogvet.com. Carthage, IL. Suzhou, China. Solutions for the Food Supply Chain. Carthage Veterinary Clinic. Hancock Veterinary Clinic. Epidemic. PEDv Worldwide. Beek , Vincent. Genetics.

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PEDv Pork Management Conference

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  1. PEDvPork Management Conference June 19, 2014 Carthage Veterinary Service, Ltd. alower@hogvet.com

  2. Carthage, IL Suzhou, China Solutions for the Food Supply Chain Carthage Veterinary Clinic Hancock Veterinary Clinic

  3. Epidemic

  4. PEDv Worldwide Beek, Vincent

  5. Genetics Woo, et al. J. Virol. 2012

  6. PEDv

  7. Swine Deltacoronavirus (SDCoV) • Non-PED coronavirus • Clinical signs similar to PED and TGE • 40% PWM for 2-3 weeks • Described in Hong Kong - 2012 • First case - June 5, 2013 • Diagnostic capabilities • SDCv PCR • No serological testing ADDL

  8. Woo, et al. J. Virol. 2012

  9. SDCoV Woo, et al. J. Virol. 2012

  10. Porcine Deltacoronavirus Bioassay • Nine - 14 day old piglets • Inoculated with PDCoV from field samples • Euthanized on: • Day 2 post-infection (PI) • Day 4 PI • Day 6 PI • Showed no evidence of enterocyte infection • Negative for PDCoV by RT-PCR University of Minnesota

  11. Porcine Deltacoronavirus Retrospective analysis • 30% positive rate on cases • Co-infection (PEDv, TGEv, RVA, RVB, RVC) • 78% positive for PEDv, RVA, RVB, and/or RVC • RVC positive >50% of the samples • 4 complete genomes • US isolates - 99.8% similar • Chinese strain - 98.9% - 99.2% similar University of Minnesota

  12. Outbreak Management

  13. PEDv Impact

  14. PEDv Impact

  15. Euthanize pigs on Day 0 – 14 days

  16. Courtesy of Dr. Jim Lowe

  17. Herd Eradication Management • Aggressive sanitation • Double de-grease, Double wash, Double disinfect rooms • 2 nights downtime • Wash sows prior to loading • No carts, change shoe • Full McREBEL • Do not touch pigs till day 7 • Wash gestation barns continuously • Wash hallways after every pig movement

  18. Antibody Response ISU. Gimenez-Lirola. NPB #13-264

  19. Song, D. Park, B, Virus Genes, 2012

  20. SDSU. Clement. NPB #13-263

  21. SDSU. Clement. NPB #13-263

  22. Conditional Vaccine License Harrisvaccines, Inc • June 16, 2014 approval • Qualifications: • Safety • Purity • Reasonable expectation of efficacy • Long term – Modified Live Vaccine

  23. PRRS and PEDv Site Classification Guidelines

  24. What do we need to learn? • Epidemiology • Watch Canada • Have they identified a key transmission route? • Feed risk • Origin of viral introduction to the US • Herd stability/eradication • Poor immune response or viral load? • Vaccine development

  25. Canadian PEDv 62 cases in Ontario Accessed on 06/16/2014. http://www.ontariopork.on.ca/ped/ComfirmedCases.aspx

  26. Carthage Veterinary Service, Ltd

  27. PEDv – Late Finishing Infection • Looseness observed 2 days prior to ADFI drop • 7 lb/day prior to break • 2 lb/day at peak - ~80% reduction 2-3 days • ADG • Reduced 31% Day 0-7 post infection • F/G • No significant difference

  28. PEDv – Late Finishing Infection Water Intake • Depressed for 7 days

  29. One positive trailer in means 1.7 positive trailers at exit

  30. Biosafety of Spray Dried Plasma Relative to PEDv • PEDv does not survive spray-drying • Experimentally inoculated spray-dried plasma loses infectivity by 7 days when stored at room temperature • Retained samples from Canadian lot of spray-dried porcine plasma and 2 other samples of PCR positive commercial spray-dried porcine plasma did not contain infective PED virus • FDA acquired samples of the specific lot were negative on bioassay • Weaned pigs fed a diet with 5% PCR positive spray-dried plasma for 14 days post weaning remained PEDv negative for the 21 day feeding period APC Tech Brief – April, 2014

  31. Biosafety of Spray Dried Plasma • Additional Questions • Is the lab simulation of spray drying similar to the actual process? • What is the sensitivity of the bioassay? • Does the lab strain of PEDv have the same survivability to the field strain? • Do all spray dry plants use the same processing parameters? • What is the variation in the plasma production process? • What are the QA/QC procedures involved?

  32. Working Group Focusing on research, control, and contamination – 4 Priorities: • To investigate the effectiveness and cost of treatments that could be used to mitigate the survival of PEDV and other viruses in feeds • To conduct contamination risk assessments at all steps within the feed processing and delivery chain • To develop a substitute for the currently used swine bioassay procedures • To continue to investigate the risk of feed and other pathways for pathogen entry into the U.S.

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