1 / 9

PDGF Receptor Beta & Chronic Myelenomonocitic Leukemia

Explore the role of PDGF Receptor Beta in Chronic Myelomonocytic Leukemia, its impact on blood cell lineage, translocations, and responsiveness to treatment. Learn about ETV6/PDGFRB transgenes and PDGFRB null mutants. Discover the implications for kidney development and hematological disorders.

dylanm
Download Presentation

PDGF Receptor Beta & Chronic Myelenomonocitic Leukemia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PDGF Receptor Beta & Chronic Myelenomonocitic Leukemia

  2. PDGFR-B is a receptor tyrosine kinase and is distinct from PDGFR-A

  3. PDGF signaling activates a number of key pathways in the cell

  4. PDGFRB null mutants showed abnormal kidney development and hematological disorders Nucleated and fragmented red blood cells

  5. ETV6/PDGFRB trangenes can lead to Chronic Myelomonocytic Leukemia Blood Cell Lineage:

  6. A variety of PDGFRB translocations are involved in myeloproliferative disorders

  7. ETV6/PDGFRB transgene leads to constitutive activation of PDGFRB kinase activity

  8. Many patients with PDFGRB rearrangements are highly responsive to imatinib (Gleevec) treatment

  9. References • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556485/pdf/emboj00087-0168.pdf • http://ac.els-cdn.com/0092867494903220/1-s2.0-0092867494903220-main.pdf?_tid=1cd20a74-2057-11e7-bb6d-00000aacb360&acdnat=1492094597_218fbe98c44994d126c93fd1f370963a • https://www.ncbi.nlm.nih.gov/pubmed/22578774 • https://www.cancer.org/cancer/chronic-myelomonocytic-leukemia/detection-diagnosis-staging.html • https://www.lls.org/leukemia/chronic-myelomonocytic-leukemia • http://www.haematologica.org/content/92/2/145 • https://www.ncbi.nlm.nih.gov/gtr/conditions/C1851585/ • http://www.nejm.org/doi/full/10.1056/NEJMoa020150

More Related