« Technological device for industrial solid-phase synthes is of peptides »

1. «Technological device for industrial solid-phase synthesis of peptides» “SynChro” Ltd. «Biomac-Innovation» General director “SynCho” Ltd. Dr. Arkavy Igor 127299, Moscow, Klara Zetkin str.4, Phone/fax: +7-095-459-91-35

2. “SynChro” Ltd. Founded in 2004 Team is 8peoples: • 3 scientists • 2 engineers • 1 technician • 1 economist • 1 manager

3. “SynChro” Ltd. Founders of “SynChro” Ltd. are: • Authors of project from the Branch of Shemyakin and Ovchinnikov Institute of Bioorganic ChemistryRAS, (Pushchino Moscow region) • «Biomac-Innovation» “SynChro” Ltd. legal form is a small enterprise.

4. Synthesis of peptides The automatic solid-phase method for peptides synthesis in automated synthesizers : • is the most perspective for manufacturing of peptides; • is used by the leading manufacturers of substances and drugs all around the world; • is complied with GMP requirements.

5. Advantages of continuous-flow synthesizer Reduction in price of synthesized product by 30% due to: • decrease in solvent consumption by more than ten times; • decrease in reagent consumption bymore than 2-4 times.

6. Laboratory unit The pilot batch of laboratory units for automatic solid-phase peptides synthesis was released in 1999, passed all tests and is using in a work till now days.

7. Key consumers

8. Positioning on the market Preparative peptides synthesizer with continuous-flow reactor (model) Estimated price is 30.000 USD Foreign industrial synthesizers of peptides with batch reactors Price: 90.000-350.000 USD Russian analogues

9. Basic segments of theworld market

10. Basic segments of the market in Russia

11. The present stage of the project

12. The present stage and future outlook for project financing Real financing Perspective financing $ 125 000 FASIE Fund (2-ndand 3-rd years of R&D) $ 25 000 FASIE Fund (1-st year of R&D) $ 300 000 Selling of unexceptional licenses Required volume of investments for 3 years $ 2 480 000 $ 360 000 Other Russian investments $ 1 430 000 Commercial credit From German Bank $ 240 000 Subventions from Land Brandenburg

13. The structure of expenditures $ 25 000 – 1 year $ 150 000 R&D $ 50 000 – 2 year $ 75 000 – 3 year LicensingCertificationMarketingPromotion $ 74 000 – 1 year $ 2480 000 $ 520 000 $ 209 000 – 2 year $ 237 000 – 3 year Application to production $ 1 570 000 $ 237 000 – 2-3 year $ 240 000 Peptides purificationand technical services

14. Suggested business-plan Manufacturing and selling of industrial synthesizers Manufacturing and selling of laboratory synthesizers Rendering services for industrial peptides synthesis and puriffication Rendering services for purification of olypeptides obtained by another methods (interferon, insulin, oxytocin, etc.) Rendering services for synthesis and purification of peptides for laboratories Manufacturing and selling of accessories, having separate application (columns, pumps, etc.) Technologies transfer

15. Next step in project realization There are certain problems with manufacturing and assembling some parts of device in Russia Biomac-Innovation Consulting Team ZAB Brainshell Biotechnopark in Berlin/Bran-denburg SynChro Ltd. Technological partner in Germany Jointmanufacturing Russian market German market

16. “SynChro” Ltd. & “Biomac-Innovation” Thank You for Your attention