1 / 9

Preliminary data on the Naples ’ cohort

Preliminary data on the Naples ’ cohort. 31.12.2012. Naples Prevent Cohort. 306 newborns from at risk families, with a confirmed case of CD among parents or sibs, were eligible for the study (01/01/2007 to 31/12/2011 ): 256 Prevent + 50 Neocel

eagan
Download Presentation

Preliminary data on the Naples ’ cohort

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Preliminary data on the Naples’ cohort 31.12.2012

  2. NaplesPreventCohort 306 newborns from at risk families, with a confirmed case of CD among parents or sibs, were eligible for the study (01/01/2007 to 31/12/2011 ): 256 Prevent + 50 Neocel • 207 newborns entered the study on the basis of DQ2/DQ8 positivity: 171 Prevent + 36 Neocel • 99 newborns were DQ2 and DQ8 negative and were followed up at 3-5 years as controls: 78 Prevent + 21 Neocel

  3. 100 mg GLUTEN WORSE THAN PLACEBO 13 new cases were registered at 36 months of follow up (CI 6%), 8% by 48 months and does not increase by 60 months (5 years).

  4. Cumulative incidence of CDby gender

  5. Cumulative incidence of CDby HLA-type (n=910) P<0.0001 14% 14% 72%

  6. Result-6:DISCRIMINANT ANALYSIS Sex, HLA risk, breastfeeding, proband: VariablesEntered/Removed(a,b,c,d) StepEnteredWilks' Lambda Statistic df1 df2 df3 Statistic df1 df2 Sig. 1 RISK ,983 1 1 185,000 3,156 1 185,000 ,077 sex ,971 2 1 185,000 2,789 2 184,000 ,064 Only 65.2% oforiginalgroupcases are correctlyclassified.

  7. % events in 16 CDcases vs 188 controls

  8. EVENTS • Celiac Cases show an excess of adverse events till 24 months: specifically they suffered from about double Upper Respiratory and Lower Respiratory Infections, more Fever lasting > 3 days , more Vomiting . • Up to 12 months they also showed more frequently Constipation. • There was no difference in the frequency of acute gastroenteritis or ‘colicky’ abdominal pain. • It is interesting to observe that such differences were not any more present after the 24 months, where most of the cases were already diagnosed and put on a gluten free diet.

  9. Conclusions • CI at 4 yearsisabout12 % • 100 MG GLUTEN AT 4 MONTHS DO NOT PREVENT , BUT MY BE WORSE IN GIRLS • HLA riskis a major riskfor the predictionofvillousatrophy, asfatherasproband. • Relevantevents in the first 2 yearsof life CDcorrelatedseem URTI and LRTI, more thangastroenteritis.

More Related