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Non-Mendelian genetics

Discover the intriguing world of non-Mendelian genetics with a focus on genomic imprinting, paramutation, maternal effects, phenotypic buffering, and the mechanisms of epigenetics such as methylation, chromatin remodeling, histone modification, and RNA interference. Delve into how epigenetic systems influence evolution, examining the selection pressures that shaped them and the significance of epigenetically inherited traits in evolutionary processes.

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Non-Mendelian genetics

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  1. Non-Mendelian genetics Gil McVean, Department of Statistics, Oxford

  2. Genomic imprinting • Parent-of-origin specific expression • Mammals, plants, insects

  3. Paramutation • Inherited interactions between homologous alleles • ‘Weak’ alleles convert ‘Strong’ alleles

  4. Maternal effects • Maternally derived products in embryos • Leads to death of non-carrier offspring

  5. Phenotypic buffering • HSP90 chaperone can ‘mask’ the deleterious effects of mutation • Block HSP90 > mutations ‘exposed’ • Select for mutations • Exposed phenotype stable even with HSP90 Rutherford & Lindquist (1998)

  6. Mechanisms of epigenetics • Methylation • Chromatin remodelling • Histone modification • RNA interference/interactions

  7. Epigenetics and evolution • What selection pressures led to the origin of epigenetic systems? • Are epigenetically inherited characters important in evolution?

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