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Cell Cycle Checkpoints

Cell Cycle Checkpoints. G1 G2 M G0. 0. G 1 checkpoint. G 0. Control system. S. G 1. G 2. M. M checkpoint. G 2 checkpoint. Cancer. Cancer is truly a disease of the cell cycle It is the unabbreviated division of a cell no longer listening to controls

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Cell Cycle Checkpoints

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  1. Cell Cycle Checkpoints • G1 • G2 • M • G0

  2. 0 G1 checkpoint G0 Control system S G1 G2 M M checkpoint G2 checkpoint

  3. Cancer • Cancer is truly a disease of the cell cycle • It is the unabbreviated division of a cell no longer listening to controls • Tumor: a collection of abnormally growing cells • Benign or malignant

  4. 0 Lymph vessels Tumor Blood vessel Glandular tissue A tumor grows from a single cancer cell. Cancer cells invade neighboring tissue. Cancer cells spread through lymph and blood vessels to other parts of the body.

  5. Metastasis

  6. Types of Cancers • Carcinoma: originate in the external or internal coverings (skin, stomach lining, intestinal lining) • Sarcoma: arise in tissues (bone, muscle) • Leukemia: arises in the blood • Lymphoma: arises in the lymph nodes

  7. Treatment • Surgery: remove tumor • Localized radiation: kills cells • Chemotherapy: drug that disrupts cell cycle

  8. We’ll talk more in depth in Ch 11…

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