1 / 18

Understanding Cell Cycle & Checkpoints in Eukaryotic Organisms

Learn about the processes of cell reproduction, growth, and repair in eukaryotic organisms through mitosis and meiosis. Explore the sequence of events in the cell cycle, including interphase, mitosis, and the role of cyclin-dependent kinases. Discover the importance of proper checkpoints in regulating cell division.

spreusser
Download Presentation

Understanding Cell Cycle & Checkpoints in Eukaryotic Organisms

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cell Cycle & Checkpoints Lecture 1

  2. Eukaryotic organisms • Heritable information is passed to the next generation via processes that include cell cycle and mitosis or meiosis plus fertilization

  3. Cell Reproduction Cell division (MITOSIS) process that forms new cells from one cell results in two cells that are identical to the original, parent cell.

  4. Importance of Cell Reproduction Growth (increase in size) Repair (replace dead or damaged cells) Asexual reproduction

  5. Cell Cycle Sequence of growth and division of a cell Growth period= Interphase Nuclear Division= mitosis

  6. Interphase Cell grows in size Carries on metabolism Chromosomes duplicate (synthesis of DNA) Preparation for mitosis (actual division into 2 identical cells)

  7. INTERPHASE = G1, S, G2 G2- Gap 2Grow Produce molecules & organelles needed for cell division MITOSIS G1- Gap 1Grow by producing proteins & organelles G0- Cell leaves cycle and stops dividingMost body cells in this phase S- Synthesis DNA replication Some can return to cycle with signal (external or internal signals) (Ex; Liver cells respond to injury)Some never divide again (Ex: Mature nerve, muscle cells)

  8. Cyclin-dependent kinases (Cdk’s) are present all the time but inactive unless combined with cyclins KINASES- Enzymes that workby adding a phosphate group to other molecules Presence of MPF (mitosis promoting factor) triggers passage past G1 & G 2 checkpoints

  9. Cyclin levels change throughout cell cycle Fluctuating levels of different Cyclin-Cdk complexesseem to control all stages of cell cycle

  10. Cyclin & Cyclin Dependent Kinases • Conserved through evolution • Genes are same across Eukaryotes

More Related