1 / 12

Molecular by-pass therapy for mitochondrial dysfunction

Molecular by-pass therapy for mitochondrial dysfunction. Howy Jacobs. IMT Tampere. Mitochondria are the power stations of our cells. ½O 2. H 2 O. Inter-membrane space. C ox. Q. H +. Complex IV. C red. QH 2. Complex II. ATP synthase. Q. NAD +. succinate. Complex III.

edith
Download Presentation

Molecular by-pass therapy for mitochondrial dysfunction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Molecular by-pass therapy for mitochondrial dysfunction Howy Jacobs IMT Tampere

  2. Mitochondria are the power stations of our cells

  3. ½O2 H2O Inter-membrane space Cox Q H+ Complex IV Cred QH2 Complex II ATP synthase Q NAD+ succinate Complex III Complex I H+ fumarate ADP NADH QH2 H+ H+ ATP The mt OXPHOS system Matrix

  4. A series of waterfalls which drive the turbine The molecular turbine that generates the electricity

  5. If a pipe conveying water to the turbines gets blocked…. … the whole system fails

  6. Power to the turbine is lost

  7. Power to the turbine is lost Pressure in the blocked pipe results in leaks and catastrophic failure

  8. When this happens in mitochondria, devastating diseases result • failure of cellular energy supply • leakage of toxic by-products (oxygen radicals) • cell death

  9. When this happens in mitochondria, devastating diseases result • fatal infantile diseases, e.g. Leigh syndrome • Parkinson's disease • tissue damage following stroke or heart attack • diabetes, deafness, epilepsy……

  10. Our strategy - to relieve blockages by a by-pass enzyme

  11. Power of the water power is still missing…. …but the turbine is now working again and there are no leaks

  12. The Project Genes for OXPHOS by-pass enzymes from 'lower' organisms • effects on normal development and physiology • resistance to toxins • curing genetic diseases of mitochondria • customizing the by-pass enzymes for therapeutic use

More Related