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Sickle-Cell Anemia. • Homozygous Dominant ( HbA , HbA ) normal hemoglobin • Homozygous Recessive ( HbS , HbS ) abnormal hemoglobin • Heterozygous ( Hb A, Hb S) normal and abnormal hemoglobin normal hemoglobin more abundant.
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Sickle-Cell Anemia • Homozygous Dominant (HbA, HbA) • normal hemoglobin • Homozygous Recessive (HbS, HbS) • abnormal hemoglobin • Heterozygous (Hb A, Hb S) • normal and abnormal hemoglobin • normal hemoglobin more abundant Note: Hemoglobin is a protein in red blood cells carrying oxygen.
Clinical Signs and Symptoms • Pain crises • Acute chest syndrome (a life-threatening pneumonia-like illness) • Cerebrovascular accidents • Splenic and renal dysfunction • Chronic anemia • Susceptibility to infections