Surgical Infections

1. Under supervision of : Dr. MOHAMMED AL-AKEELY Surgical Infections

2. infection Invasion of the body by pathogenic microorganisms and reaction of the host to organisms and their toxins

3. A surgical infection is an infection which requires surgical treatment and has developed befor, or as a complication of surgical treatment.

4. could be life threatening • Accounts for 1/3 of surgical patients • Increased cost to healthcare

5. Some imp defin. • Bacteremia: bacteria in blood • SIRS: systemic inflammatory response syndrome (fever, tachycardia, tachypnea, leukocytosis) • Sepsis: documented infection & SIRAS • Septic shock: sepsis & hypotension refractory to fluid resuscitation

6. Principles of surgical treatment • Debridement-necrotic, injured, dead tissue • Drainage-abscess, infected fluid • Removal-infection source, foreign body • Supportive measures: • immobilization • elevation • antibiotics

7. Common organisms Gram positive bacteria: Streptococci Staphylococci Clostridia Gram negative bacteria: Pseudomonas E. coli Bacteroidfragilis

8. Streptococcal infections Cellulitis Lymphangitis Lymphadenitis Necrotizing faciitis

9. cellulitis severe inflammation of dermal and subcutaneous layers of the skin. caused by normal skin flora(group A strept /staph)or by exogenous bacteria. the bacteria can spread rapidly, entering the lymph nodes and the bloodstream and spreading throughout the body. In rare cases, the infection can spread to the deep layer of tissue (Necrotizing faciitis). often occurs in broken skin.

10. cellulitis Signs & symptoms: affected area is red, hot, and tender with vague borders. Most common sites :Face, hand and lower extremities. RF:old age & immunodeficiency. Diagnosis:clinically. TX: 1- resting, elevation of the affected limb, debridement. 2- ampicillin/amoxicillin in moderate (suspected strept) + flucloxacillin or dicloxacillin for mild (staph)

11. cellulitis

12. Erysipelas Erysipelasis the term used for a more superficial infection of the dermis and upper subcutaneous layer that presents clinically with raised surface and well defined edge. Erysipelas and cellulitis often coexist, so it is often difficult to make a distinction between the two.

13. Erysipelas

14. Lymphangitis Lymphangitis is an inflammation of the lymphatic channels that occurs as a result of infection at a site distal to the channel. Streptococcus pyogenes. Signs and symptoms: deep reddening of the skin, warmth, with moderate pain and swelling. Lymphadenitis, chills and a high fever along. ( appears as red streak).

15. Lymphangitis Tx: 1-elevate and immobilize affected areas to reduce swelling, pain, and the spread of infection. 2- antibiotic.

16. Lymphangitis

17. LYMPHADENITIS • Lymphadenitis is an infection of the lymph nodes. • Lymphadenitis may occur after skin infections or other bacterial infections, particularly those due to streptococcus or staphylococcus. • Swollen, tender, or hard lymph nodes • Red, tender skin over lymph node • Lymph nodes may feel rubbery if an abscess has formed.

18. LYMPHADENITIS • Treatment may include: • Antibiotics to treat any underlying infection • Analgesics (pain killers) to control pain • Anti-inflammatory medications to reduce inflammation and swelling • Cool compresses to reduce inflammation and pain • Surgery may be needed to drain any abscess.

19. LYMPHADENITIS

20. Necrotizing fasciitis (flesh-eating disease) Infection and necrosis of the deeper layers of skin and subcutaneous tissues. 2 types: l:polymicrobial ll: monomicrobial(mostly group A strept) Signs and symptoms: The infection begins locally, at a site of trauma>>intense pain>> then tissue becomes swollen (hrs.) Common sites: abdominal wall, perineum, and limbs. Diagnosis:visual examination & microscopic evaluation of tissue samples.

21. Necrotizing fasciitis RF:diabetes, abdominal surgery, drug addict and trauma. Tx: 1-Early medical treatment (combination of intravenous antibiotics including penicillin, vancomycin, and clindamycin) 2-Cultures are taken to determine appropriate antibiotic 3-aggressive surgical debridement ( no definitive boundries!!) High mortality rate(75%) if left untreated.

22. Necrotizing fasciitis

23. Staphylococcal Infections Abscess: is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body As Staphylococcus aureus bacteria is a common cause, an anti-staphylococcus antibiotic such as flucloxacillin or dicloxacillin is used Incision and drainage is a common surgical intervention in case of abscess

24. Staphylococcal Infections • Furuncle- infection of one hair follicle / sweat glands • Carbuncle-extension of furuncle into subcut. Tissue with possible formation of abscess. “usually more than one furuncle” common in diabetic patient common sites- back, back of neck Treatment: drainage, antibiotics, control diabetes

25. Staphylococcal Infections

26. Clostridial infections Gas gangrene Tetanus Pseudomembranous colitis

27. GAS GANGRENE is a bacterial infection that produces gas in gangrenous tissues usually caused by Clostridium perfrengins bacteria. It is a medical emergency (Progression to toxemia and shock is often very rapid) Large wounds contaminated by soil. It results in rapid myonecrosis, swelling, seropurulent discharge, foul smelling wound, crepitus in subcutaneous tissue.

28. GAS GANGRENE X-ray: gas in muscle and under skin. Tx: 1-Wound exposure, debridement , drainage. 2-Penicillin, clindamycin, metronidazole 3-Hyperbaric oxygen chamber

29. GAS GANGRENE

30. TETANUS • Cl. Tetani, produce neurotoxin • Penetrating wound ( rusty nail, thorn ) • Incubation period: 7-10 days • Usually wound healed when symptoms appear • Trismus- first symptom, stiffness in neck & back • Anxious look with mouth drawn up ( risussardonicus) • Progressive dysphasia, dysphagia, dyspnea & tonic convulsion Death by exhaustion, aspiration or asphyxiation

31. TETANUS Treatment: wound debridement Muscle relaxants, penicillin ventilatory support Prophylaxis: vaccination by HTIG & T toxoid in tetanus prone wound in patient with unknown or incomplete history of immunization. If it is more than 5 years since last dose of tetanus immunization give only T toxoid.

32. PSEUDOMEMBRANOUSCOLITIS Superinfection in patients in long term oral antibiotic therapy Cl. Difficile Watery diarrhea, abdominal pain, fever Diagnosis needs Sigmoidoscopy, stool- culture and toxin assay Treatment : stop offending antibiotic oral vancomycin/ metronidazole rehydration, isolate patient

33. Pseudomonas Opportunestic bacteria that may cause surface infections, but may also cause serious and lethal infection. Enter the body through minor skin abrasion, ventilator tubes, urinary catheters and IV lines >>> therefore it iscommon in ICU. Can cause septecimia (particularly in burn wounds) Tx: aminoglycosides, piperacillin, ceftazidine.

34. E. coli Normal intestinal flora, facultative anearobes. May cause circulatory collapse (due to endotoxin), wound infections, meningitis, endocarditis, abdominal abscess & UTI. Tx: ampicillin, aminoglycosides, cephalosporine.

35. Bacteroidesfragilis Normal flora of mouth and colon, anearobic. Produce foul smelling pus, gas in surrounding tissues & necrosis. Responsible for intraabdominal & gyne. infection. Causes spiking fever, jaundice & leukocytosis. Tx: Surgical drainage, excision. Clindamycin, metronidazole.

36. Hospital aquired infections • The most common is UTI • The most common causing death is pneumonia.

37. Surgical site infection (SSI) • 38% of all surgical infections • Infection within 30 days of operation • Classification: Superficial: Superficial SSI–infection in subcutaneous plane (47%) Deep:Subfascial SSI-muscle plane (23%) Organ/ space SSI-intra-abdominal, other spaces (30%) • Staph. aureus- most common organism • E coli, Entercoccus ,other Entetobacteriaceae- deep infections B fragilis – intrabd. abscess

38. Surgical site infection (SSI) • Risk factors: age, malnutrition, obesity, immunocompromised, poor surg. tech, prolonged surgery, preop. shaving and type of surgery. • Diagnosis: Sup.SSI- erythema, oedema, discharge and pain Deep infections- no local signs, fever, pain, hypotension. need investigations. • Treatment:surgical / radiological intervention.

39. Surgical site infection (SSI) Intra-abdominal infections • Generalized • Localized • Prevention- good tech., avoid bowel injury, good anastomosis. • Diagnosis- History, exam., investigations CT scan. • Treatment- surgery/ intervention Antibiotics (aerobe+ anaerobe)

40. UTI • UTI are usually consequences of foleycathetar. • The most common symptoms of a bladder infection are burning with urination (dysuria), frequency of urination and an urge to urinate. • may also present with flank pain and a fever.

41. UTI • Diagnostic test: • -urinalysis (nitrate, estrase) • -culture • -urine microscopy (WBC>10) • The common org. is: • - E. coli, klebsiella, enterococcus & staph. aureus

42. TREATMENT • Ab.with gram (-) spectrum -sulphamethoxasole -trimethoprim -gentamycin -ceprofloxacin • Check culture &sensitivity

43. pneumonia Rout of infection: -gross aspiration during anesthesia or intubation. Pathogen includes anaerobic organism & gram(-) bacilli. -Atelectasis: the collapsed lung may become secondarily infected -contiguous spread from another site.

44. pneumonia Sing & symptoms : • People with pneumonia often have one or more of these symptoms: Fever, productive cough, shortness of breath, hypoxia and chest pain. • Chest x-ray & sputum culture are important to confirm the diagnose.

45. treatment Hospital acquired pneumonia generally treated by cefuroxime, ceftriaxone for the usual pathogen( gram(-), s.aureus , strept.pn, & H. influenzae) + treatment of other pathogen. if there is recent Hx of abd.surg the infectious org. is anaerobes we should add clindamycin

46. If the pt. is comatose or has head trauma, DM, or renal failure the org. usually is s.aureus & there is risk of MRSA we add vancomycin If the pt. take high dose of glucocorticoides the org. usually is legionella we add macrolide (azithromycin)

47. If the pt. has malnutrition, structural lung disease, glucocorticoid therapy the org. usually is pseudomonas.a Also if the pt. has Hx of neuro.surg. ,head trauma, ARDS, aspiration the org. usually is acinetobacter spp. All of them treated by the standard treatment + aminoglycoside or ciprofloxacin IV + antipseudomonal penicillin or imipenem.

48. Sterilization and Disinfection • Sterilization means ERADICATING all microorganisms and SPORES. • Disinfection means the eradication of vegetative form only leaving SPORES. • For sterilization, autoclave is the most common instrument used. • Antiseptic is used on the surface of the body like alcohol, chlorohexidine • Disinfectent is applied on metals and other instruments like formaldehyde = formalin • Plastic materials are best sterilized using chemicals while metalic instrument can be safely sterilized in the autoclave.

49. antibiotics • Chemotherapeutic agents that act on organisms • Bacteriocidal:Penicillin,Cephalosporin, Vancomycin, Aminoglycosides • Bacteriostatic:Erythromycin,Clindamycin,Tetracycline

50. COMMON ANTIBIOTICS • Penicillins- penicillin G • Cephalosporins (II, III)-Cefruoxime, Ceftriaxone • Aminoglycosides- Gentamycin • Fluoroquinolones- Ciprofloxacin • Glycopeptides- Vancomycin • Macrolides- Erythromycin, • Tetracyclines-, Doxycycline