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WHI Investigators Meeting

WHI Investigators Meeting. May 3-4, 2012. Status of follow-up: Extension II. WHI Productivity-Ancillary Studies. Funding success. 2009 – 38 submitted, 17 funded, 45% 2010 – 40 submitted, 16 funded, 40% 2011 – 41 submitted, 7 funded 17% with 11 still pending. Robert Brunner,

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WHI Investigators Meeting

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  1. WHI Investigators Meeting May 3-4, 2012

  2. Status of follow-up: Extension II

  3. WHI Productivity-Ancillary Studies

  4. Funding success • 2009 – 38 submitted, 17 funded, 45% • 2010 – 40 submitted, 16 funded, 40% • 2011 – 41 submitted, 7 funded 17% with 11 still pending

  5. Robert Brunner, Chair, Ancillary Studies Committee

  6. ASC members • Co-chair, Marian Neuhouser • Garnet Anderson • Tim Assimes • Bette Caan • Charles Eaton • Gerardo Heiss • Li Jiao • Karen Johnson • Lew Kuller • Jennifer Lin • Simin Liu • Gloria Sarto • Eric Whitsel

  7. Publications and Presentations Cynthia Thomson Barbara Howard

  8. P&P Members • Peggye Dilworth-Anderson • Hoda Anton-Culver • Rowan Chlebowski • Laura Coker • Jennifer Hays-Grudo • Keri Monda • Kari North • Mary Jo O’Sullivan • Ross Prentice • Stephen Rapp • Sylvia Smoller • Lesley Tinker • Robert Wallace • Jean Wactawski-Wende • Linda Van Horn • Shirley Beresford • Giselle Corbie-Smith • Mark Espeland • Nora Franceschini • Margery Gass • Jane Kotchen • Andrea LaCroix • Simin Liu • Yvonne Michael • Jacques Rossouw • Michael Simon • Sally Shumaker • Marcia Stefanick

  9. Top 10 lead authors: Rowan Chlebowski, Ross Prentice, Geoffrey Kabat, Judith Hsia, JoAnn Manson, Jacques Rossouw, Zhao Chen, Mark Espeland, Barbara Howard, Karen Margolis

  10. Outcomes Advisory Committee • Marian Limacher, Chair • Karen Margolis, Co-chair • Matt Allison • Charles Eaton • Susan Heckbert • Charles Kooperberg • Joyce Noonan (OC Rep.) • Marcia Ko • Andrea LaCroix • KamakshiLakshminarayan • Shari Ludlam • Bernedine Lund • Jennifer Robinson

  11. Outcomes status • Extension I cases adjudication complete except • Retrospective DVT cases (N=300, target completion, 8/2012) • HF • All 11,000 cancer Extension I cases have been coded • Since 10/01/10 • 7990 outcomes identified • 5992 cases were sent forward adjudication • Electronic adjudication has been implemented for CVD/fracture/death outcomes • Abstraction of HF cases is moving forward at UNC

  12. Cancers identified in WHI

  13. Adjudicators • Carl Chelius • Eric Whitsel • George Hess • Judith Hsia • Karen Margolis • Kathryn Rexrode • Kim Miller • Linda Loes • Marcia Ko • Marian Limacher • Maurizio Trevisan • Stephanie Connelly • Steve Sidney • Susan Heckbert • Beth Lewis • Charles Eaton • Matt Allison • Stroke • Amie Hsia • Brian Silver • Enrique Leira • Jana Wold • Jose Merino • KamakshiLakshminarayan • Lenore Ocava • John Lynch

  14. New Initiatives • Long-Life Study (CCC)/OPACH (Andrea LaCroix, PI) • Consent mailings started in February—1602 consented • Visits started in March—381 completed, 532 scheduled • Projected completion of visits by second quarter 2013 • Clinical Trial working group (Mark Espeland, chair) • Reviewed 19 concept proposals • Selected 2 to support for studywide effort • Manson and Sesso • Factorial design of 2 dietary supplements, alpha linoleic acid and cacao • 10,000 women at elevated CVD risk • Stefanick • A pragmatic trial of physical activity

  15. Resources • Sharepoint • Access at www.whiscience.org • Data enclave • Physical enclave in place • Seeking CMS/IRB approval for virtual enclave • Medicare data • CCC has files covering 1991-2010 • Application for Part D has been developed • Annual updates expected • Regional Center Analysts

  16. Scientific Interest Groups & Chairs • Aging: Stephen Rapp • Bone, Fracture and Body Composition: Carolyn Crandall, Jean Wactawski-Wende • Cancer: Bette Caan, Ross Prentice, Rowan Chlebowski • Cardiovascular Disease: Marcia Stefanick • Genetics, Proteomics & Biomarkers: Rebecca Jackson • Health Services: Karen Margolis • Minorities and Health Disparities: Laura Coker

  17. Scientific Interest Groups & Chairs • Nutrition/Energy Balance: Marian Neuhouser • Diabetes and Obesity: Lesley Tinker, Jean Wactawski-Wende • Physical and Built Environment: Eric Whitsel • Physical Activity: Marcia Stefanick • Psychosocial & Behavioral Health: Sally Shumaker

  18. Rebecca Jackson, SRWG chair

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