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Sequential Metabolic Reactions on a Chip: A Step Toward Energy Production to Power Implantable Medical Nanodevices

Sequential Metabolic Reactions on a Chip: A Step Toward Energy Production to Power Implantable Medical Nanodevices. Alexander J. Travis V.M.D., Ph.D. Baker Institute for Animal Health Cornell University College of Veterinary Medicine February 25, 2009. Challenge: How can medical

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Sequential Metabolic Reactions on a Chip: A Step Toward Energy Production to Power Implantable Medical Nanodevices

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  1. Sequential Metabolic Reactions on a Chip: A Step Toward Energy Production to Power Implantable Medical Nanodevices Alexander J. Travis V.M.D., Ph.D. Baker Institute for Animal Health Cornell University College of Veterinary Medicine February 25, 2009

  2. Challenge: How can medical nanodevices be powered within a body? ATP ATP ATP http://www.steve.gb.com/images/science/phospholipid_liposome.png

  3. Challenge: How can complex medical nanodevices be powered within a body?

  4. Challenge: How can complex medical nanodevices be powered within a body?

  5. Challenge: How can complex medical nanodevices be powered within a body?

  6. head midpiece mitochondria end-piece fibrous sheath principal piece Schematic of a mammalian sperm based on B.P. Setchell, p. 64 in Reproduction in Mammals 1

  7. Schematic of the fibrous sheath of the principal piece based on B.P. Setchell, p. 69 in Reproduction in Mammals 1

  8. Glycolysis * * * *

  9. Recombinant HK1 and GPI were made with a His tag

  10. Recombinant HK1 and GPI were active when bound to a Ni-NTA surface

  11. Recombinant HK1 and GPI were active when bound to a Ni-NTA surface

  12. Adsorption and specific activity of His-GPI versus GPI randomly adsorbed

  13. Sequential activities of His-HK and His-GPI on the same chip

  14. Sequential activities of His-HK and His-GPI on the same chip

  15. Schematic of a complex medical nanodevice

  16. Travis lab • Atsushi Asano • Danielle Buttke • Nicole Dean • Yeunhee Kim • Chinatsu Mukai • Jacquelyn Nelson • Vimal Selvaraj • Magnus Bergkvist • Funding • Cornell Institute for Biotechnology & Life Science Technologies • Baker Institute for Animal Health

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