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LUNG TRANSPLANTATION

LUNG TRANSPLANTATION. Overall. ISHLT. 2007. J Heart Lung Transplant 2007;26: 782-795. 2169. 1915. 1791. 1788. 1591. 1579. 1462. 1479. 1458. 1370. 1369. 1231. 1088. 922. 707. 418. 189. 83. 15. 46. 14. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE.

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LUNG TRANSPLANTATION

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  1. LUNG TRANSPLANTATION Overall ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  2. 2169 1915 1791 1788 1591 1579 1462 1479 1458 1370 1369 1231 1088 922 707 418 189 83 15 46 14 NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide. ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  3. AVERAGE CENTER VOLUMELung Transplants: January 1, 1998 - June 30, 2006 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  4. DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUMELung Transplants: January 1, 2000 - June 30, 2006 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  5. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS(1/1985-6/2006) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  6. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  7. LUNG TRANSPLANTS:Donor Age by Year of Transplant ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  8. DONOR AGE DISTRIBUTION FOR LUNG TRANSPLANTS(1/1985-6/2006) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  9. DONOR AGE DISTRIBUTION FOR LUNG TRANSPLANTS BY ERA ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  10. LUNG TRANSPLANTATION Adult Recipients ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  11. AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS(1/1985-6/2006) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  12. Mean age by era 1985-1995 = 45.0 years 1996-6/2006 = 48.9 years AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  13. Mean age by era 1985-1994 = 44.7 years 1995-1999 = 47.3 years 2000-6/2006 = 49.5 years AGE DISTRIBUTION OF ADULT LUNG TRANSPLANT RECIPIENTS BY ERA ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  14. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival (Transplants: January 1994 - June 2005) P < 0.0001 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  15. ADULT LUNG TRANSPLANTATION: Indications(1/1995-6/2006) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  16. ADULT LUNG TRANSPLANTATION: Distribution of Procedure Type for Major Indications(1991-2005) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  17. ADULT LUNG TRANSPLANTATIONProcedure Type within Indication, by Year ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  18. ADULT LUNG TRANSPLANTATION: Indications for Single Lung Transplants (Transplants: January 1996 - June 2006) *Other includes: Sarcoidosis: 2.1% Bronchiectasis: 0.4% Congenital Heart Disease: 0.2% LAM: 0.7% OB (non-ReTx): 0.6% Miscellaneous: 5.4% ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  19. ADULT LUNG TRANSPLANTATION: Indications for Bilateral/Double Lung Transplants (Transplants: January 1996 - June 2006) *Other includes: Sarcoidosis: 2.8% Bronchiectasis: 5.1% Congenital Heart Disease: 1.4% LAM: 1.2% OB (non-ReTx): 1.1% Miscellaneous: 5.6% ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  20. ADULT LUNG TRANSPLANTATIONIndications By Year (%) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  21. ADULT LUNG TRANSPLANTATIONIndications By Year (Number) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  22. ADULT LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  23. ADULT LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  24. ADULT LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  25. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Era (Transplants: January 1988 – June 2005) Survival comparisons by era 1988-94 vs. 1995-99: p = 0.0057 1988-94: vs. 2000-6/05: p <0.0001 1995-99 vs. 2000-6/05: p <0.0001 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  26. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  27. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Gender(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  28. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2005) Survival comparisons Alpha-1 vs. CF: p = 0.0031CF vs. COPD: p < 0.0001 Alpha-1 vs. COPD: p = 0.0005 CF vs. IPF: p < 0.0001 Alpha-1 vs. IPF: p <0.0001 CF vs. PPH: p = 0.0001 Alpha-1 vs. PPH: p = 0.0007 CF vs. Sarcoidosis: p = 0.0002 Alpha-1 vs. Sarcoidosis p = .0492 COPD vs. IPF: p <0.0001 Note: Other comparisons are not statistically different. ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  29. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1990 – June 2005) Survival comparisons Alpha-1 vs. CF: p =.0472 PPH vs. COPD: p < 0.0001 Alpha-1 vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001 Alpha-1 vs. IPF: p < 0.0001IPF vs. Sarcoidosis: p = 0.0209 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 Note: Other comparisons are not statistically different. ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  30. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2005) Survival comparisons Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. COPD: p < 0.0001 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001 COPD vs. Sarcoidosis: p < 0.0001 IPF vs. Sarcoidosis: p = 0.0002 Note: Other comparisons are not statistically different. ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  31. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2005) Survival comparisons Alpha-1 vs. CF: p = 0.0031 Alpha-1 vs. COPD p = 0.0005 Alpha-1 vs. IPF p < 0.0001 Alpha-1 vs. PPH: p = 0.0007 Alpha-1 vs. Sarcoidosis: p = 0.0492 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 CF vs. PPH: p < 0.0001 CF vs. Sarcoidosis: p = 0.0002 COPD vs. IPF: p <0.0001 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  32. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  33. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  34. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival for Eisenmenger’s Syndrome(Transplants: January 1990 – June 2005) N= 38 N= 15 p = 0.2632 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  35. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type(Transplants: January 1990 – June 2005)Diagnosis: Alpha-1 Antitrypsin Deficiency N at risk at 10 years is 87 for Single Lung and 74 for Double Lung. P = 0.0001 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  36. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type and Age (Transplants: January 1990 – June 2005)Diagnosis: Alpha-1 Antitrypsin Deficiency p = 0.0724 N at risk at 10 years: Single Lung, <50 = 57; Double Lung, <50 = 62; Single Lung, 50+ = 30; Double Lung, 50+ = 12 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  37. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2005) Diagnosis: Emphysema/COPD P < 0.0001 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  38. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Age(Transplants: January 1990 – June 2005) Diagnosis: Emphysema/COPD P < 0.0001 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  39. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type(Transplants: January 1990 – June 2005)Diagnosis: Idiopathic Pulmonary Fibrosis P = 0.0301 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  40. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2005)Diagnosis: Primary Pulmonary Hypertension P = 0.0532 ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  41. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2005) Diagnosis: Emphysema/COPD, Single Lung ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  42. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2005) Diagnosis: Emphysema/COPD, Double Lung ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  43. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2005) Diagnosis: Idiopathic Pulmonary Fibrosis, Single Lung ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  44. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2005) Diagnosis: Idiopathic Pulmonary Fibrosis, Double Lung ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  45. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Donor CMV status/Recipient CMV status(Transplants: October 1999 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  46. ADULT LUNG TRANSPLANTS (1995-6/2005)Risk Factors for 1 Year Mortality (N=10,415) *Other = All diagnoses other than COPD, PPH, IPF, cystic fibrosis, pulmonary fibrosis,bronchiectasis,alpha-1 antitrypsin deficiency, and LAM. ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  47. ADULT LUNG TRANSPLANTS (1995-6/2005)Risk Factors for 1 Year Mortality (N=10,415) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  48. ADULT LUNG TRANSPLANTS (1995-6/2005)Risk Factors for 1 Year Mortality (N=10,415) ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  49. ADULT LUNG TRANSPLANTS(1/1995-6/2005)Risk Factors for 1 Year Mortality ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

  50. ADULT LUNG TRANSPLANTS(1/1995-6/2005)Risk Factors for 1 Year MortalityRecipient Age ISHLT 2007 J Heart Lung Transplant 2007;26: 782-795

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